{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:28:38Z","timestamp":1791300518569,"version":"4.1.0"},"reference-count":16,"publisher":"The Journal of Rheumatology","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Autoantibodies are frequently found in adult patients with polymyositis (PM), dermato-myositis (DM), and overlap myositis disorders. They are less common in pediatric patients with myositis. We investigated the autoantibody pattern in a pediatric Argentine Caucasian cohort to characterize novel autoantibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Sera from children that satisfied published criteria for idiopathic inflammatory myopathy were analyzed for autoantibodies by RNA and protein immunoprecipitation and immunoblotting techniques. Routine myositis-specific and myositis-associated autoantibodies as well as autoantibody specificities were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>We tested sera from 64 consecutive pediatric myositis patients, including 40 with juvenile DM, 7 with juvenile PM, and 17 with overlap myositis syndromes. Sixteen (25%) patients were found to have anti-MJ autoantibody exclusively, which appears to identify a subset of pediatric myositis patients with severe disease characterized by muscle contractures and atrophy and significant compromise of functional status. Fourteen (22%) patients were found to have an antibody targeting 2 proteins of 155 and 140 kDa. Other myositis-specific autoantibodies were uncommon in this pediatric cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>A newly recognized autoantibody, anti-MJ, was the most common antibody found in this Argentine pediatric cohort. The clinical features indicated that this antibody is distinct from other reported antibodies in pediatric patients with myositis.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.090461","type":"journal-article","created":{"date-parts":[[2009,10,16]],"date-time":"2009-10-16T00:45:53Z","timestamp":1255653953000},"page":"2547-2551","source":"Crossref","is-referenced-by-count":112,"title":["Clinical and Serologic Characterization of an Argentine Pediatric Myositis Cohort: Identification of a Novel Autoantibody (anti-MJ) to a 142-kDa Protein"],"prefix":"10.3899","volume":"36","author":[{"given":"GRACIELA","family":"ESPADA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOSE A.","family":"MALDONADO COCCO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NOREEN","family":"FERTIG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHESTER V.","family":"ODDIS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2009,10,15]]},"reference":[{"key":"2018112909212388000_36.11.2547.1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/00005792-197707000-00001","article-title":"Computer assisted analysis of 153 patients with polymyositis and dermatomyositis","volume":"56","author":"Bohan","year":"1977","journal-title":"Medicine"},{"key":"2018112909212388000_36.11.2547.2","unstructured":"Kasukawa R Tojo T Miyawaki S Preliminary diagnostic criteria for classification of mixed connective tissue disease. In: Kasukawa R Sharp GC , editors. Mixed connective tissue disease and antinuclear antibodies. Amsterdam: Elsevier, Excerpta Medica; 1987:41\u20137."},{"key":"2018112909212388000_36.11.2547.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80807-9"},{"key":"2018112909212388000_36.11.2547.4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1949.02900430001001"},{"key":"2018112909212388000_36.11.2547.5","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350114"},{"key":"2018112909212388000_36.11.2547.6","doi-asserted-by":"publisher","DOI":"10.1002\/art.10760"},{"issue":"Suppl","key":"2018112909212388000_36.11.2547.7","first-page":"S139","article-title":"Clinical and serological characterization of the anti-MJ antibody in childhood myositis [abstract]","volume":"40","author":"Oddis","year":"1997","journal-title":"Arthritis Rheum"},{"key":"2018112909212388000_36.11.2547.8","doi-asserted-by":"publisher","DOI":"10.1002\/art.22164"},{"key":"2018112909212388000_36.11.2547.9","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780371019"},{"key":"2018112909212388000_36.11.2547.10","first-page":"1794","article-title":"Clinical significance of specific autoantibodies in juvenile dermatomyositis","volume":"23","author":"Feldman","year":"1996","journal-title":"J Rheumatol"},{"issue":"Suppl","key":"2018112909212388000_36.11.2547.11","first-page":"S518","article-title":"Autoantibodies to transcriptional intermediary factor 1-gamma (TIF1-\u03b3) in dermatomyositis [abstract]","volume":"54","author":"Targoff","year":"2006","journal-title":"Arthritis Rheum"},{"key":"2018112909212388000_36.11.2547.12","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel161"},{"key":"2018112909212388000_36.11.2547.13","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem359"},{"key":"2018112909212388000_36.11.2547.14","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem265"},{"issue":"Suppl","key":"2018112909212388000_36.11.2547.15","first-page":"S787","article-title":"Sera with autoantibodies to the MJ antigen react with NXP2. [abstract]","volume":"56","author":"Targoff","year":"2007","journal-title":"Arthritis Rheum"},{"key":"2018112909212388000_36.11.2547.16","doi-asserted-by":"publisher","DOI":"10.1002\/art.22862"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.090461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T17:33:57Z","timestamp":1543512837000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.090461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,15]]},"references-count":16,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2009,11,5]]},"published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.3899\/jrheum.090461"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.090461","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,15]]}}}