{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:28:01Z","timestamp":1791300481167,"version":"4.1.0"},"reference-count":44,"publisher":"The Journal of Rheumatology","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To compare anti-PM\/Scl autoantibody-associated interstitial lung disease (ILD) with anti-aminoacyl-tRNA synthetases (anti-ARS) autoantibody-associated ILD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We retrospectively studied 21 patients with ILD from a department of respiratory medicine, including 9 with anti-PM\/Scl autoantibodies (6 women, median age 55 yrs, followup 5.5 yrs) and 12 with anti-ARS autoantibodies (6 women, median age 59 yrs, followup 2.3 yrs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Pulmonary manifestations in patients with anti-PM\/Scl autoantibody-associated ILD usually followed the extrapulmonary manifestations of the connective tissue disease (CTD) (7\/9 cases). The predominant imaging features on initial high resolution computed tomography were ground-glass attenuation and reticular opacities, and mainly suggested nonspecific interstitial pneumonia in both groups. CTD was classified as dermatomyositis (DM; 2), undifferentiated CTD (2), cutaneous limited systemic sclerosis (2), rheumatoid arthritis (RA; 1), and overlap syndrome (1) in the anti-PM\/Scl group; and polymyositis (4), undifferentiated CTD (5), DM (1), amyopathic DM (1), and RA (1) in the anti-ARS group. Frequencies of arthralgia, Raynaud phenomenon, cutaneous rash, and mechanic\u2019s hands were comparable in both groups. Myalgia or muscle weakness was present in 0\/9 PM\/Scl and 5\/12 ARS patients (p &lt; 0.05). More than 1 autoantibody was present in 11 patients. ILD worsened despite treatment in 4 patients with anti-PM\/Scl autoantibodies and 2 with anti-ARS autoantibodies, and included 1 death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Anti-PM\/Scl and anti-ARS antibodies are associated with similar clinical manifestations, with the exception only of more overt myositis in the latter, therefore challenging the clinical specificity of the antisynthetase syndrome.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.090652","type":"journal-article","created":{"date-parts":[[2010,3,16]],"date-time":"2010-03-16T02:56:18Z","timestamp":1268708178000},"page":"1000-1009","source":"Crossref","is-referenced-by-count":63,"title":["Interstitial Lung Disease Associated with Anti-PM\/Scl or Anti-Aminoacyl-tRNA Synthetase Autoantibodies: A Similar 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