{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:30:11Z","timestamp":1791649811045,"version":"4.3.4"},"reference-count":37,"publisher":"The Journal of Rheumatology","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To evaluate the intraobserver and interobserver reproducibility of B-mode and power Doppler (PD) sonography in patients with active long-standing rheumatoid arthritis (RA) comparatively with clinical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>In each of 7 patients being considered for a change in their RA treatment regimen, 7 healthcare professionals examined the 28 joints used in the Disease Activity Score 28-joint count (DAS28). Then 7 sonographers examined each of the 7 patients twice, using previously published B-mode and PD grading systems. The clinical reference standard was presence of synovitis according to at least 4\/7 examiners. The sonographic reference standard was at least grade 1 (ALG1) or 2 (ALG2) synovitis according to at least 4\/7 sonographers. Interobserver reproducibility of sonography was assessed versus the sonographer having the best intraobserver reproducibility. Agreement was measured by Cohen\u2019s kappa statistic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Intraobserver and interobserver reproducibility of B-mode and PD used separately was fair to good. Agreement between clinicians and sonographers at all sites using B-mode, PD, and both was 0.46, 0.37, and 0.36, respectively, for grade 1 synovitis; and 0.58, 0.19, and 0.19 for grade 2 synovitis. The number of joints with synovitis was smaller by physical examination (36.7%) than by B-mode with ALG1 (58.6%; p &lt; 0.001). The number of joints with synovitis was higher by physical examination than by PD with both ALG1 (17.8%; p &lt; 0.0001) and ALG2 (6.6%; p &lt; 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>PD findings explain most of the difference between clinical and sonographic joint assessments for synovitis in patients with long-standing RA.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.090881","type":"journal-article","created":{"date-parts":[[2010,3,16]],"date-time":"2010-03-16T02:56:18Z","timestamp":1268708178000},"page":"938-945","source":"Crossref","is-referenced-by-count":39,"title":["Reproducibility of Joint Swelling Assessment by Sonography in Patients with Long-lasting Rheumatoid Arthritis (SEA-Repro Study Part II)"],"prefix":"10.3899","volume":"37","author":[{"given":"SANDRINE","family":"JOUSSE-JOULIN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIA ANTONIETTA","family":"d\u2019AGOSTINO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"THIERRY","family":"MARHADOUR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JEAN DAVID","family":"ALBERT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JACQUES","family":"BENTIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ISABELLE","family":"CHARY VALCKENAERE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FABIEN","family":"ETCHEPARE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PHILIPPE","family":"GAUDIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTOPHE","family":"HUDRY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00c9RARD","family":"CHAL\u00c8S","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LAURENT","family":"GRANGE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00c9CILE","family":"HACQUARD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAMIEN","family":"LOEUILLE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00c9R\u00c9MIE","family":"SELLAM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MAXIME","family":"DOUGADOS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALAIN","family":"SARAUX","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2010,3,15]]},"reference":[{"key":"2018112909230167000_37.5.938.1","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1148\/radiology.198.2.8596870","article-title":"Power Doppler sonography of synovitis: assessment of therapeutic response \u2014 preliminary observations","volume":"198","author":"Newman","year":"1996","journal-title":"Radiology"},{"key":"2018112909230167000_37.5.938.2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199911)42:11<2303::AID-ANR7>3.0.CO;2-4"},{"key":"2018112909230167000_37.5.938.3","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3109\/03009749309095131","article-title":"Ultrasound examination of metacarpophalangeal joints in rheumatoid arthritis","volume":"22","author":"Grassi","year":"1993","journal-title":"Scand J Rheumatol"},{"key":"2018112909230167000_37.5.938.4","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200109)44:9<2018::AID-ART350>3.0.CO;2-C"},{"key":"2018112909230167000_37.5.938.5","doi-asserted-by":"publisher","DOI":"10.1002\/art.20054"},{"key":"2018112909230167000_37.5.938.6","doi-asserted-by":"crossref","unstructured":"Marhadour T Jousse-Joulin S Chal\u00e8s G Grange L Hacquard C Loeuille D Reproducibility of joint swelling assessments in long-lasting rheumatoid arthritis: Influence on Disease Activity Score-28 values (SEA-Repro Study Part I). 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