{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:20:35Z","timestamp":1783696835768,"version":"3.55.0"},"reference-count":34,"publisher":"The Journal of Rheumatology","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To verify the hypothesis that blockade of CD28 costimulation by treatment with abatacept in patients with rheumatoid arthritis (RA) might induce a reduction in the number of CD28\u2013 T cells, as well as other effector T cell populations. We evaluated whether these variations correlate with clinical response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Peripheral blood T cell subsets were longitudinally evaluated by flow cytometry through the analysis of CD28, CD45RA, and CCR7 expression in 16 patients with RA who were treated with abatacept.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>After 48 weeks of treatment, the proportion and the absolute number of circulating CD8+CD28\u2013 T cells decreased (p = 0.008, p = 0.055, respectively, compared with baseline), as well as the proportion of the CD8+CD45RA+CCR7\u2013 cells, thought to represent terminally differentiated effector T cells (p = 0.03). Reductions of percentages of circulating CD4+CD28\u2013 and CD8+CD28\u2013 T cells, and (CCR7\u2013) CD8+ total effector T cells were directly correlated with the reduction of Disease Activity Score 28 C-reactive protein (r = 0.58, p = 0.014; r = 0.47, p = 0.059; r = 0.59, p = 0.012, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>After therapy with abatacept, circulating CD28\u2013 T cells and other effector populations decrease in patients with RA. This decrease is correlated with clinical response.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.091176","type":"journal-article","created":{"date-parts":[[2010,3,16]],"date-time":"2010-03-16T02:56:18Z","timestamp":1268708178000},"page":"911-916","source":"Crossref","is-referenced-by-count":59,"title":["Decreased Circulating CD28-negative T Cells in Patients with Rheumatoid Arthritis Treated with Abatacept Are Correlated with Clinical 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