{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:26:04Z","timestamp":1760189164171},"reference-count":21,"publisher":"The Journal of Rheumatology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Genetic components play important roles in the incidence and development of ankylosing spondylitis (AS). Aminopeptidase regulator of tumor necrosis factor receptor shedding 1 (<jats:italic>ERAP1<\/jats:italic>) was recently found to be associated with AS in North American and British cohorts. We evaluated whether<jats:italic>ERAP1<\/jats:italic>is associated with AS in a Chinese Han population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>A sample of 50 patients and 50 healthy controls was recruited for preliminary screening for informative single-nucleotide polymorphisms (SNP). Then 6 SNP of suggestive significance in the initial screening were followed up in a large sample of 471 patients with AS and 456 ethnically matched controls. Diagnosis of AS followed the 1984 modified New York criteria. Linkage disequilibrium coefficient (D\u2019 and r<jats:sup>2<\/jats:sup>) and haplotypes were estimated by Haploview.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result.<\/jats:title><jats:p>Two SNP (rs27434, p = 0.00039, and rs27529, p = 0.0083) in<jats:italic>ERAP1<\/jats:italic>other than that reported previously were found to be significantly associated with AS. Haplotype analysis using 5 SNP within 1 linkage disequilibrium block identified 2 risk haplotypes (GATGT and GACGT) and 1 protective haplotype (GGTGT) for AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Our study demonstrated that 2 novel SNP in<jats:italic>ERAP1<\/jats:italic>were associated with AS in the Han Chinese population, suggesting that<jats:italic>ERAP1<\/jats:italic>might confer genetic risk for AS in Han Chinese through the common mechanism shared by different populations, although the AS-associated SNP in<jats:italic>ERAP1<\/jats:italic>might be population-specific.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.100013","type":"journal-article","created":{"date-parts":[[2010,11,16]],"date-time":"2010-11-16T05:14:47Z","timestamp":1289884487000},"page":"317-321","source":"Crossref","is-referenced-by-count":26,"title":["<i>ERAP1<\/i>Is Associated with Ankylosing Spondylitis in Han 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