{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T05:27:24Z","timestamp":1781846844901,"version":"3.54.5"},"reference-count":30,"publisher":"The Journal of Rheumatology","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To identify early predictors of sacroiliac (SI) involvement in a cohort of patients with enthesitis-related arthritis (ERA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>During a 7-year followup period, all consecutive patients fulfilling the ILAR classification criteria for ERA were enrolled. Data collected included demographic, clinical and laboratory variables at disease onset, at the onset of inflammatory back pain, and at the last available followup visit. Pelvis radiographs and dynamic magnetic resonance imaging (MRI) scans for SI joints were obtained simultaneously in all patients who developed inflammatory back pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Fifty-nine children with ERA were studied; 40 male, 19 female; median age at disease onset 9 years 4 months (range 6 yrs 6 mo \u2013 13 yrs 3 mo). At a median interval after disease onset of 1 year 3 months, 21 children reported symptoms of inflammatory back pain. In all cases, radiographs of SI joints were negative, while dynamic MRI revealed acute sacroiliitis in 17 cases. Multivariate analysis showed that the early predictors of SI were the number of active joints (p &lt; 0.03) and the number of active entheses (p &lt; 0.001) at onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>In our cohort, roughly 30% of children with ERA\/juvenile idiopathic arthritis develop clinical and MRI evidence of sacroiliitis, detectable with dynamic MRI as early as 1 year after disease onset. Additional data from larger case series are needed to assess the specificity and sensitivity of this technique in the early phase of the disease and to confirm the rate of SI involvement reported in this cohort.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.100090","type":"journal-article","created":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T21:01:20Z","timestamp":1283374880000},"page":"2395-2401","source":"Crossref","is-referenced-by-count":99,"title":["Early Predictors of Juvenile Sacroiliitis in Enthesitis-related Arthritis"],"prefix":"10.3899","volume":"37","author":[{"given":"ILARIA","family":"PAGNINI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SARA","family":"SAVELLI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARCO","family":"MATUCCI-CERINIC","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CLAUDIO","family":"FONDA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROLANDO","family":"CIMAZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GABRIELE","family":"SIMONINI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2010,9,1]]},"reference":[{"key":"2018112909250888000_37.11.2395.1","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty","year":"2004","journal-title":"J Rheumatol"},{"key":"2018112909250888000_37.11.2395.2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1053\/berh.2002.0247","article-title":"The juvenile-onset spondyloarthritides: rationale for clinical evaluation","volume":"16","author":"Burgos-Vargas","year":"2002","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2018112909250888000_37.11.2395.3","doi-asserted-by":"publisher","DOI":"10.1002\/art.22181"},{"key":"2018112909250888000_37.11.2395.4","first-page":"2140","article-title":"Genuine ankylosing spondylitis in children: a case-control study of patients with early definite disease according to adult onset criteria","volume":"23","author":"Burgos-Vargas","year":"1996","journal-title":"J Rheumatol"},{"key":"2018112909250888000_37.11.2395.5","doi-asserted-by":"crossref","unstructured":"Burgos-Vargas R . 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