{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T04:13:13Z","timestamp":1769573593634,"version":"3.49.0"},"reference-count":31,"publisher":"The Journal of Rheumatology","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Patients with ankylosing spondylitis (AS) can suffer concurrently from inflammatory bowel disease (IBD), as ulcerative colitis (UC) or Crohn\u2019s disease (CD). Serological markers have been described to diagnose IBD. We investigated IBD serological markers in AS patients without IBD and whether these antibodies enable differentiating patients with AS and IBD from those without IBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Frequencies of perinuclear antineutrophil cytoplasmic antibodies (pANCA), antibodies to the cell-wall mannan of <jats:italic>Saccharomyces cerevisiae<\/jats:italic> (ASCA), and antibodies to porin protein C of <jats:italic>Escherichia coli<\/jats:italic> (OmpC) were evaluated in 179 patients: 52 with AS, 50 with UC, 51 with CD, and 26 with IBD and AS. Patient groups were matched for age and sex. All AS patients fulfilled the 1984 modified New York criteria. IBD was ascertained by clinical, endoscopic, and microscopic findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>In 55% of the AS patients without manifest IBD at least one antibody associated with IBD was observed. pANCA, ASCA (IgA and\/or IgG), and OmpC antibodies were found in 21%, 30%, and 19% of the AS patients, respectively. pANCA was more frequently present in AS with concurrent UC than in AS alone (OR 8.2, 95% CI 1.2\u201355.6), thus being an indicator for UC in AS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Antibodies associated with IBD are detectable in more than half of AS patients without symptoms or signs of IBD. A relatively recent marker in this setting, OmpC antibodies, does not contribute to the differentiation between AS and type of IBD. Presence of pANCA, however, is significantly increased in AS patients who also have UC, and is an indicator to perform endoscopy. These results corroborate a pathophysiological link between AS and IBD.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.100269","type":"journal-article","created":{"date-parts":[[2010,9,2]],"date-time":"2010-09-02T01:01:20Z","timestamp":1283389280000},"page":"2340-2344","source":"Crossref","is-referenced-by-count":35,"title":["pANCA, ASCA, and OmpC Antibodies in Patients with Ankylosing Spondylitis without Inflammatory Bowel Disease"],"prefix":"10.3899","volume":"37","author":[{"given":"MIRJAM","family":"de VRIES","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IRENE","family":"van der HORST-BRUINSMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"INGRID","family":"van HOOGSTRATEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ADRIAAN","family":"van BODEGRAVEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARY","family":"von BLOMBERG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HANA","family":"RATNAWATI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BEN","family":"DIJKMANS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2010,9,1]]},"reference":[{"key":"2018112909250876000_37.11.2340.1","first-page":"2667","article-title":"Inflammatory eye, skin, and bowel disease in spondyloarthritis: genetic, phenotypic, and environmental factors","volume":"28","author":"Brophy","year":"2001","journal-title":"J Rheumatol"},{"key":"2018112909250876000_37.11.2340.2","first-page":"2860","article-title":"Spondyloarthropathy is underestimated in inflammatory bowel disease: prevalence and HLA association","volume":"27","author":"de Vlam","year":"2000","journal-title":"J Rheumatol"},{"key":"2018112909250876000_37.11.2340.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2006.03.010"},{"issue":"Pt 1","key":"2018112909250876000_37.11.2340.4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0016-5085(89)91557-6","article-title":"Ileocolonoscopy in seronegative spondylarthropathy","volume":"96","author":"De Vos","year":"1989","journal-title":"Gastroenterology"},{"key":"2018112909250876000_37.11.2340.5","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/26.5.338"},{"key":"2018112909250876000_37.11.2340.6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/art.1780370105","article-title":"High frequency of silent inflammatory bowel disease in spondylarthropathy","volume":"37","author":"Leirisalo-Repo","year":"1994","journal-title":"Arthritis Rheum"},{"key":"2018112909250876000_37.11.2340.7","first-page":"1538","article-title":"Evidence of subclinical intestinal inflammation by 99m technetium leukocyte scintigraphy in patients with HLA-B27 positive juvenile onset active spondyloarthropathy","volume":"27","author":"Lionetti","year":"2000","journal-title":"J Rheumatol"},{"key":"2018112909250876000_37.11.2340.8","first-page":"1542","article-title":"Gut inflammation in the spondyloarthropathies: clinical, radiologic, biologic and genetic features in relation to the type of histology. 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