{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:21:07Z","timestamp":1791462067087,"version":"4.3.4"},"reference-count":19,"publisher":"The Journal of Rheumatology","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To identify the risk of hip and vertebral fractures in patients with rheumatic disorders (RD) and inflammatory bowel diseases (IBD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>This population-based case-control study assessed the fracture risk of patients with rheumatoid arthritis, juvenile idiopathic arthritis (JIA), ankylosing spondylitis (AS), systemic lupus erythematosus, polymyositis\/dermatomyositis (PM\/DM), systemic sclerosis (SSc), Crohn\u2019s disease, and ulcerative colitis (UC). The study cohort comprised 53,108 patients with fracture (66% women) and 370,602 age-matched and sex-matched controls. Conditional logistic regression analysis was performed and results were expressed as OR with corresponding 95% CI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>There was a statistically significant increased fracture risk for all RD and for IBD compared with controls. The magnitude of fracture risk was higher for patients with RD (OR 3, 95% CI 2.9\u20133.2) than for those with IBD (OR 1.6, 1.4\u20131.8). The OR in RD ranged from 2.6 (1.3\u20134.9) for SSc to 4 (3.4\u20134.6) for AS. The largest increased fracture risk for vertebral fractures was seen in AS (OR 7.1, 6\u20138.4) and for hip fractures in JIA (OR 4.1, 2.4\u20136.9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Our results highlight the existence of an increased fracture risk from a variety of underlying causes in patients with RD and IBD. In many inflammatory diseases, implementation of fracture prevention strategies may be beneficial.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.100363","type":"journal-article","created":{"date-parts":[[2010,10,2]],"date-time":"2010-10-02T00:55:50Z","timestamp":1285980950000},"page":"2247-2250","source":"Crossref","is-referenced-by-count":122,"title":["Increased Fracture Risk in Patients with Rheumatic Disorders and Other Inflammatory Diseases \u2014 A Case-Control Study with 53,108 Patients with Fracture: Table 1."],"prefix":"10.3899","volume":"37","author":[{"given":"R\u00dcDIGER J.","family":"WEISS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIUS C.","family":"WICK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PAUL W.","family":"ACKERMANN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SCOTT M.","family":"MONTGOMERY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2010,10,1]]},"reference":[{"key":"2018112909250887000_37.11.2247.1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21110"},{"key":"2018112909250887000_37.11.2247.2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.1.49"},{"key":"2018112909250887000_37.11.2247.3","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/art.1780271205","article-title":"Fractures after rheumatoid arthritis. 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