{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:38:01Z","timestamp":1780411081117,"version":"3.54.1"},"reference-count":41,"publisher":"The Journal of Rheumatology","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>25-hydroxy-vitamin D (25-OH-D) insufficiency\/deficiency is increasingly prevalent and has been associated with many chronic diseases, including rheumatoid arthritis (RA). Our purpose was to define the prevalence and associations of 25-OH-D insufficiency\/deficiency in a cohort of US veterans with RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Vitamin D status (25-OH-D) was assessed in patients with RA using radioimmunoassay on banked plasma collected at enrollment. Insufficiency was defined as concentrations &lt; 30 ng\/ml and deficiency as &lt; 20 ng\/ml. Associations of 25-OH-D insufficiency\/deficiency with patient characteristics obtained at enrollment were examined using multivariate logistic regression, adjusting for age, sex, season of enrollment, and race.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Patients (850 men, 76% Caucasian) had a mean (SD) age of 64 (SD 11.3) years. The prevalences of 25-OH-D insufficiency and deficiency were 84% and 43%, respectively. After multivariate adjustment, both insufficiency and deficiency were more common with anti-cyclic citrullinated peptide antibody positivity and non-Caucasian race, and in the absence of vitamin D supplementation. 25-OH-D deficiency, but not insufficiency, was independently associated with higher tender joint counts and highly sensitive C-reactive protein levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>In a predominantly elderly, male RA population, 25-OH-D insufficiency was highly prevalent. With the increasing adverse health outcomes associated with hypovitaminosis D, screening and supplementation, particularly among minority, seropositive patients with RA, should be performed routinely.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.100516","type":"journal-article","created":{"date-parts":[[2010,10,16]],"date-time":"2010-10-16T00:29:54Z","timestamp":1287188994000},"page":"53-59","source":"Crossref","is-referenced-by-count":105,"title":["Prevalence of Vitamin D Insufficiency\/Deficiency in Rheumatoid Arthritis and Associations with Disease Severity and Activity"],"prefix":"10.3899","volume":"38","author":[{"given":"GAIL S.","family":"KERR","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IRAJ","family":"SABAHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOHN 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