{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:50:41Z","timestamp":1791010241818,"version":"4.1.0"},"reference-count":14,"publisher":"The Journal of Rheumatology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To study the frequency and characteristics of patients with Wegener\u2019s granulomatosis (WG) strictly and persistently localized to one organ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Retrospective analysis of the French Vasculitis Study Group (FVSG) WG cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Sixteen patients (3.2% of the cohort) were identified who had isolated lung nodules, ear-nose-throat, or ocular involvement that did not progress to systemic disease (median followup, 58 mo) over the period of observation. Ten received first-line therapy with cyclophosphamide, which was effective in 4. Cotrimoxazole alone achieved remission in one, combined with corticosteroids in 3. Eight required subsequent treatments because of first-line failure or relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Strictly and persistently localized WG is uncommon. Optimal treatment remains to be determined.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.100518","type":"journal-article","created":{"date-parts":[[2010,12,2]],"date-time":"2010-12-02T05:19:23Z","timestamp":1291267163000},"page":"475-478","source":"Crossref","is-referenced-by-count":33,"title":["Wegener\u2019s Granulomatosis Strictly and Persistently Localized to One Organ Is Rare: Assessment of 16 Patients from the French Vasculitis Study Group 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