{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:52:00Z","timestamp":1793638320375,"version":"4.5.1"},"reference-count":12,"publisher":"The Journal of Rheumatology","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>The common polymorphism rs4994 [c. T387C, p. Trp64Arg (W64R)] of the lipolysis regulator beta-3-adrenergic receptor (<jats:italic>ADRB3<\/jats:italic>) was identified as a marker in the pathogenesis of hyperuricemia. As gout is characterized by elevated serum concentrations of uric acid, we investigated <jats:italic>ADRB3<\/jats:italic> as a potential candidate for gout.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>This was a prospective case-control study in a group of 421 male patients with gout and 312 gout-free male controls to genotype the single-nucleotide polymorphism rs4994 of <jats:italic>ADRB3<\/jats:italic> gene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Our results showed that the C allele carrier confers a significantly higher risk for development of gout [chi-square = 4.91, df = 1, p = 0.027, OR 1.95 (adjusted by age, total cholesterol level, and body mass index), 95% CI 1.22\u20133.13 by dominant mode]. There was significantly higher uric acid level in carriers of the Arg64\/Arg64 genotype in controls compared to non-carriers (480.5 mmol\/l vs 315.0 mmol\/l, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p><jats:italic>ADRB3<\/jats:italic> rs4994 polymorphism is a potential candidate for the pathogenesis of gout in a male Chinese population.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.101037","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T21:49:20Z","timestamp":1296596960000},"page":"738-740","source":"Crossref","is-referenced-by-count":12,"title":["Positive Correlation Between Beta-3-Adrenergic Receptor (<i>ADRB3<\/i>) Gene and Gout in a Chinese Male 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