{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:25:44Z","timestamp":1780471544453,"version":"3.54.1"},"reference-count":20,"publisher":"The Journal of Rheumatology","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Our aim was to determine areal bone mineral density (BMD<jats:sub>a<\/jats:sub>) and disease-related factors linked with BMD<jats:sub>a<\/jats:sub> in adults with a history of juvenile idiopathic arthritis (JIA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Men and women with a history of JIA attending a young adult rheumatology clinic in Newcastle, UK, underwent dual energy x-ray absorptiometry (DEXA) of the lumbar spine and total hip. Information was obtained about disease duration and subtype, previous treatment including corticosteroid and methotrexate therapy, and large-joint replacement. Subjects completed the modified Health Assessment Questionnaire (HAQ). Blood was taken for assessment of C-reactive protein, erythrocyte sedimentation rate, and rheumatoid factor (RF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Seventy-one women and 16 men, mean age 28.7 and 31.4 years, and mean disease duration 20.6 and 24.0 years, respectively, were studied. Mean BMD<jats:sub>a<\/jats:sub> was 0.982 (Z-score = \u22120.328; 95% CI \u22120.657, 0.001) and 1.028 g\/cm<jats:sup>2<\/jats:sup> (Z-score = \u22120.251; 95% CI \u22121.266, 0.764) in women and men, respectively, at the spine and 0.817 (Z-score = \u22120.542; 95% CI \u22120.975, \u22120.109) and 0.857 g\/cm<jats:sup>2<\/jats:sup> (Z-score = \u22120.176; 95% CI \u22122.323, 1.971) at the hip. After adjusting for age and sex, increasing HAQ score was associated with both lower spine BMD<jats:sub>a<\/jats:sub> and hip BMD<jats:sub>a<\/jats:sub>. Compared with patients with oligoarticular disease, those with enthesitis-related arthritis had higher BMD<jats:sub>a<\/jats:sub> at the spine, while those with extended oligoarticular and polyarticular RF-negative disease had lower hip BMD<jats:sub>a<\/jats:sub>. Oral corticosteroids and the presence of a large-joint replacement were associated with lower BMD<jats:sub>a<\/jats:sub> at both the spine and hip.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>There was a trend toward low BMD<jats:sub>a<\/jats:sub> in women with a history of JIA. These patients may be at risk of the complications of osteoporosis including fragility fractures and should be considered for targeted preventive measures.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.101232","type":"journal-article","created":{"date-parts":[[2011,6,16]],"date-time":"2011-06-16T01:06:43Z","timestamp":1308186403000},"page":"1689-1693","source":"Crossref","is-referenced-by-count":29,"title":["Bone Health in Adult Men and Women with a History of Juvenile Idiopathic Arthritis"],"prefix":"10.3899","volume":"38","author":[{"given":"JUDITH","family":"THORNTON","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STEPHEN R.","family":"PYE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TERENCE W.","family":"O\u2019NEILL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAVID","family":"RAWLINGS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROGER M.","family":"FRANCIS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DEBORAH P.M.","family":"SYMMONS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DARREN M.","family":"ASHCROFT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HELEN E.","family":"FOSTER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2011,6,15]]},"reference":[{"key":"2018112909264431000_38.8.1689.1","first-page":"2450","article-title":"Development of bone mineral density at the lumbar spine and femoral neck in juvenile chronic arthritis\u00e2\u0080\u0094a prospective one year followup study","volume":"25","author":"Kotaniemi","year":"1998","journal-title":"J Rheumatol"},{"key":"2018112909264431000_38.8.1689.2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11097"},{"key":"2018112909264431000_38.8.1689.3","doi-asserted-by":"publisher","DOI":"10.1002\/art.20963"},{"key":"2018112909264431000_38.8.1689.4","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050189"},{"key":"2018112909264431000_38.8.1689.5","first-page":"38","article-title":"Effects of rheumatic disease and corticosteroid treatment on calcium metabolism and bone density in children assessed one year after diagnosis, using stable isotopes and dual energy x-ray absorptiometry","volume":"58","author":"Perez","year":"2000","journal-title":"J Rheumatol"},{"key":"2018112909264431000_38.8.1689.6","doi-asserted-by":"publisher","DOI":"10.1007\/s002230001090"},{"key":"2018112909264431000_38.8.1689.7","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200007)43:7<1504::AID-ANR13>3.0.CO;2-0"},{"key":"2018112909264431000_38.8.1689.8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/03009749950155733","article-title":"Weight-bearing physical activity, calcium intake, systemic glucocorticoids, chronic inflammation, and body constitution as determinants of lumbar and femoral bone mineral in juvenile chronic arthritis","volume":"28","author":"Kotaniemi","year":"1999","journal-title":"Scand J Rheumatol"},{"key":"2018112909264431000_38.8.1689.9","first-page":"1073","article-title":"Bone mineral content and bone mineral metabolism: changes after growth hormone treatment in juvenile chronic arthritis","volume":"27","author":"Rooney","year":"2000","journal-title":"J Rheumatol"},{"key":"2018112909264431000_38.8.1689.10","first-page":"990","article-title":"Bone mineral density and turnover in children with systemic juvenile chronic arthritis","volume":"25","author":"Brik","year":"1998","journal-title":"J Rheumatol"},{"issue":"Suppl","key":"2018112909264431000_38.8.1689.11","first-page":"S119","article-title":"Pathological fractures and osteoporosis in a cohort of 103 systemic onset juvenile idiopathic arthritis patients [abstract]","volume":"43","author":"Murray","year":"2000","journal-title":"Arthritis Rheum"},{"key":"2018112909264431000_38.8.1689.12","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.048835"},{"key":"2018112909264431000_38.8.1689.13","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199904)42:4<790::AID-ANR24>3.0.CO;2-G"},{"key":"2018112909264431000_38.8.1689.14","first-page":"1065","article-title":"Osteopenia in adults with a history of juvenile rheumatoid arthritis. 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