{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T13:40:29Z","timestamp":1712670029763},"reference-count":15,"publisher":"The Journal of Rheumatology","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2011,10]]},"abstract":"Objective.<\/jats:title>Two interferon regulatory factor 5 (IRF5<\/jats:italic>) gene variants were examined for association with rheumatoid arthritis (RA).<\/jats:p><\/jats:sec>Methods.<\/jats:title>A total of 2300 patients with RA and 1836 controls were recruited from 2 independent RA studies in Sweden. One insertion-deletion polymorphism (CGGGG indel) and one single-nucleotide polymorphism (rs10488631) in theIRF5<\/jats:italic>gene were genotyped and analyzed within RA subgroups stratified by rheumatoid factor (RF) and anticitrullinated peptide antibodies (ACPA).<\/jats:p><\/jats:sec>Results.<\/jats:title>The CGGGG indel was preferentially associated with the RF-negative (OR 1.29, p = 7.9 \u00d7 10\u22125<\/jats:sup>) and ACPA-negative (OR 1.27, p = 7.3 \u00d7 10\u22125<\/jats:sup>) RA subgroups compared to the seropositive counterparts. rs10488631 was exclusively associated within the seronegative RA subgroups (RF-negative: OR 1.24, p = 0.016; ACPA-negative: OR 1.27, p = 4.1 \u00d7 10\u22123<\/jats:sup>).<\/jats:p><\/jats:sec>Conclusion.<\/jats:title>Both the CGGGG indel and rs10488631 are relevant for RA susceptibility, especially for seronegative RA.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.110322","type":"journal-article","created":{"date-parts":[[2011,8,2]],"date-time":"2011-08-02T02:17:02Z","timestamp":1312251422000},"page":"2130-2132","source":"Crossref","is-referenced-by-count":10,"title":["Preferential Association of Interferon Regulatory Factor 5 Gene Variants with Seronegative Rheumatoid Arthritis in 2 Swedish Case-Control Studies"],"prefix":"10.3899","volume":"38","author":[{"given":"CHUAN","family":"WANG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HEIDI","family":"KOKKONEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHANNA 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