{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:48:42Z","timestamp":1789886922559,"version":"4.0.1"},"reference-count":14,"publisher":"The Journal of Rheumatology","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To compare the respective effects of tocilizumab (TCZ) monotherapy, etanercept (ETN) monotherapy, and adalimumab (ADA) monotherapy on arterial stiffness in patients with rheumatoid arthritis (RA) in an open-label, randomized controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Patients with RA were eligible if they had active disease (28-joint Disease Activity Score &gt; 3.2) and no prior treatment with methotrexate or biologics. All 64 patients had no history of cardiovascular disease or steroid treatment. Patients were randomly assigned to receive TCZ alone (n = 22), ETN alone (n = 21), or ADA alone (n = 21). Arterial stiffness was assessed with cardio-ankle vascular index (CAVI) and aortic augmentation index normalized to a fixed heart rate of 75 bpm (AIx@75) at baseline and 24 weeks\u2019 followup. Clinical data were collected at regular visits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>The characteristics of each group at baseline were not significantly different. In all groups there was significant attenuation from baseline to 24 weeks in CAVI (Week 0-Week 24, TCZ: 0.85 \u00b1 0.15 m\/s, p = 0.02; ETN: 0.81 \u00b1 0.18 m\/s, p = 0.03; ADA: 0.90 \u00b1 0.21 m\/s, p = 0.02) and in AIx@75. There were no significant differences among the groups in measures of CAVI or AIx@75. The 3 therapies made no difference to carotid intima-media thickness and carotid artery plaque. Only TCZ increased fasting serum total cholesterol from baseline to 24 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>The 3 types of monotherapy limited arterial stiffness in patients with RA to a similar extent.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.110340","type":"journal-article","created":{"date-parts":[[2011,8,2]],"date-time":"2011-08-02T02:17:02Z","timestamp":1312251422000},"page":"2169-2171","source":"Crossref","is-referenced-by-count":89,"title":["Tocilizumab Monotherapy Reduces Arterial Stiffness as Effectively as Etanercept or Adalimumab Monotherapy in Rheumatoid Arthritis: An Open-label Randomized Controlled Trial"],"prefix":"10.3899","volume":"38","author":[{"given":"KENSUKE","family":"KUME","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KANZO","family":"AMANO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SUSUMU","family":"YAMADA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KAZUHIKO","family":"HATTA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIROYUKI","family":"OHTA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NORIKO","family":"KUWABA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2011,8,1]]},"reference":[{"key":"2018112909270285000_38.10.2169.1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"2018112909270285000_38.10.2169.2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390105"},{"key":"2018112909270285000_38.10.2169.3","doi-asserted-by":"publisher","DOI":"10.5551\/jat.13.101"},{"key":"2018112909270285000_38.10.2169.4","first-page":"2388","article-title":"Increased augmentation index in rheumatoid arthritis and its relationship to coronary artery atherosclerosis","volume":"34","author":"Avalos","year":"2007","journal-title":"J Rheumatol"},{"key":"2018112909270285000_38.10.2169.5","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.086157"},{"key":"2018112909270285000_38.10.2169.6","doi-asserted-by":"publisher","DOI":"10.1002\/art.10269"},{"key":"2018112909270285000_38.10.2169.7","doi-asserted-by":"publisher","DOI":"10.1177\/0003319710371620"},{"key":"2018112909270285000_38.10.2169.8","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(81)90149-0"},{"key":"2018112909270285000_38.10.2169.9","doi-asserted-by":"publisher","DOI":"10.1002\/art.11465"},{"key":"2018112909270285000_38.10.2169.10","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1253\/circj.72.598","article-title":"Cardio-ankle vascular index is a candidate predictor of coronary atherosclerosis","volume":"72","author":"Nakamura","year":"2008","journal-title":"Circ J"},{"key":"2018112909270285000_38.10.2169.11","doi-asserted-by":"publisher","DOI":"10.1002\/art.20407"},{"key":"2018112909270285000_38.10.2169.12","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1303-y"},{"key":"2018112909270285000_38.10.2169.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01723-0"},{"key":"2018112909270285000_38.10.2169.14","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.22.2685"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.110340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T18:04:38Z","timestamp":1543514678000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.110340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,1]]},"references-count":14,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2011,10,1]]},"published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.3899\/jrheum.110340"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.110340","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,1]]}}}