{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:55:08Z","timestamp":1780469708977,"version":"3.54.1"},"reference-count":22,"publisher":"The Journal of Rheumatology","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To analyze the attainment of inactive disease following initiation of tumor necrosis factor-\u03b1 (TNF-\u03b1) inhibitors in a heterogeneous cohort of children with juvenile idiopathic arthritis (JIA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We performed retrospective chart review of all children with JIA at 1 academic center who had started TNF-\u03b1 inhibitor therapy. We retrospectively determined inactive disease status according to the 2004 criteria of Wallace,<jats:italic>et al<\/jats:italic>. We evaluated inactive disease status at 1 year after initiation of TNF-\u03b1 inhibitor and attainment of inactive disease at any point during the study period. Predictors of inactive disease were determined using univariate analyses and multivariable logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>A total of 125 patients started TNF-\u03b1 inhibitors, and 88 patients had data available for the 1-year followup visit. Many patients (49%) started TNF-\u03b1 inhibitors within 6 months of the diagnosis of JIA. Diverse JIA phenotypes were represented: at baseline, 29% of all patients had active enthesitis and only 23% had active polyarthritis. At the 1-year followup, 36 of 88 (41%) patients had inactive disease. Overall, 67 of 125 (54%) patients ever attained inactive disease status during the study period. In multivariable models, enthesitis-related arthritis (ERA) and higher Childhood Health Assessment Questionnaire (CHAQ) scores at baseline were independently associated with failure to later attain inactive disease status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Treatment with TNF-\u03b1 inhibitors appears to be less effective for attaining inactive disease status in patients with ERA or higher baseline CHAQ scores. Further studies are needed regarding the clinical effectiveness of TNF-\u03b1 inhibitor therapy and the optimal treatment of ERA.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.110427","type":"journal-article","created":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T16:52:17Z","timestamp":1321462337000},"page":"2675-2681","source":"Crossref","is-referenced-by-count":47,"title":["Attainment of Inactive Disease Status Following Initiation of TNF-\u03b1 Inhibitor Therapy for Juvenile Idiopathic Arthritis: Enthesitis-related Arthritis Predicts Persistent Active Disease"],"prefix":"10.3899","volume":"38","author":[{"given":"KATHERINE J.","family":"DONNITHORNE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RANDY Q.","family":"CRON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TIMOTHY","family":"BEUKELMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2011,11,15]]},"reference":[{"key":"2018112909271682000_38.12.2675.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003163421103"},{"key":"2018112909271682000_38.12.2675.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706290"},{"key":"2018112909271682000_38.12.2675.3","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.014886"},{"key":"2018112909271682000_38.12.2675.4","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.087411"},{"key":"2018112909271682000_38.12.2675.5","doi-asserted-by":"publisher","DOI":"10.1002\/art.24777"},{"key":"2018112909271682000_38.12.2675.6","doi-asserted-by":"publisher","DOI":"10.1186\/ar2619"},{"key":"2018112909271682000_38.12.2675.7","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty","year":"2004","journal-title":"J Rheumatol"},{"key":"2018112909271682000_38.12.2675.8","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep144"},{"key":"2018112909271682000_38.12.2675.9","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq292"},{"key":"2018112909271682000_38.12.2675.10","first-page":"1","article-title":"Early rheumatoid arthritis \u00e2\u0080\u0094 Is there a window of opportunity?","volume":"80","author":"Cush","year":"2007","journal-title":"J Rheumatol Suppl"},{"key":"2018112909271682000_38.12.2675.11","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/acr.20069","article-title":"Clinical course and prognostic value of disease activity in the first two years in different subtypes of juvenile idiopathic arthritis","volume":"62","author":"Albers","year":"2010","journal-title":"Arthritis Care Res"},{"key":"2018112909271682000_38.12.2675.12","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.143347"},{"key":"2018112909271682000_38.12.2675.13","first-page":"234","article-title":"Juvenile idiopathic arthritis classification criteria: Loopholes and diagnosis software","volume":"34","author":"Behrens","year":"2007","journal-title":"J Rheumatol"},{"key":"2018112909271682000_38.12.2675.14","first-page":"2290","article-title":"Preliminary criteria for clinical remission for select categories of juvenile idiopathic arthritis","volume":"31","author":"Wallace","year":"2004","journal-title":"J Rheumatol"},{"key":"2018112909271682000_38.12.2675.15","doi-asserted-by":"publisher","DOI":"10.1002\/art.21121"},{"key":"2018112909271682000_38.12.2675.16","first-page":"2055","article-title":"Prolonged efficacy of etanercept in refractory enthesitis-related arthritis","volume":"31","author":"Henrickson","year":"2004","journal-title":"J Rheumatol"},{"key":"2018112909271682000_38.12.2675.17","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20044"},{"key":"2018112909271682000_38.12.2675.18","doi-asserted-by":"crossref","unstructured":"Petty RE Cassidy JT . Enthesitis-related arthritis (juvenile ankylosing spondylitis). In: Cassidy JT Petty RE Laxer RM Lindsley CB , editors. Textbook of pediatric rheumatology. Philadelphia: Saunders; 2010:272\u00e2\u0080\u009386.","DOI":"10.1016\/B978-1-4160-6581-4.10017-2"},{"key":"2018112909271682000_38.12.2675.19","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20460"},{"key":"2018112909271682000_38.12.2675.20","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1002\/1529-0131(199707)40:7<1202::AID-ART3>3.0.CO;2-R","article-title":"Preliminary definition of improvement in juvenile arthritis","volume":"40","author":"Giannini","year":"1997","journal-title":"Arthritis Rheum"},{"key":"2018112909271682000_38.12.2675.21","first-page":"1335","article-title":"Enthesalgia in childhood: Site-specific tenderness in healthy subjects and in patients with seronegative enthesopathic arthropathy","volume":"30","author":"Sherry","year":"2003","journal-title":"J Rheumatol"},{"key":"2018112909271682000_38.12.2675.22","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.087593"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.110427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T19:43:33Z","timestamp":1713123813000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.110427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,15]]},"references-count":22,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2011,12,1]]},"published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.3899\/jrheum.110427"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.110427","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,15]]}}}