{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:00:23Z","timestamp":1762542023802},"reference-count":27,"publisher":"The Journal of Rheumatology","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Systemic sclerosis (SSc) is an autoimmune chronic fibrotic disorder. Urotensin II (U-II) is predominantly a vasoactive peptide with fibrotic and prothrombotic features. Like endothelin-1 (ET-1), U-II could play an important role in SSc pathogenesis. We evaluated the possible role of the U-II gene polymorphisms (Thr21Met and Ser89Asn) in the genetic susceptibility to SSc in a Turkish population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>A total of 189 patients with SSc and 205 healthy controls were enrolled in our study. We analyzed the genotype and allele frequencies of the U-II (<jats:italic>UTS2<\/jats:italic>) gene polymorphisms Thr21Met and Ser89Asn in patients with SSc and in controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>We found that the Thr21Met polymorphism of the <jats:italic>UTS2<\/jats:italic> gene was markedly associated with the risk of developing SSc (p &lt; 0.0001), but there was no relationship between the Ser89Asn polymorphism and SSc (p &gt; 0.05). Two haplotypes (MS and TS) were markedly associated with SSc (p &lt; 0.05). There were significant associations between the genotype and allele frequencies of <jats:italic>UTS2<\/jats:italic> gene Thr21Met polymorphism and cases with diffuse or limited SSc, systemic or lung involvement, finger flexion deformity, pitting scars at the fingertips, positive anticentromere, or positive antitopoisomerase 1 antibody groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Our study shows the association between Thr21Met, but not Ser89Asn, in the <jats:italic>UTS2<\/jats:italic> gene and SSc. The results strongly suggest that this single-nucleotide polymorphism may be an important risk factor in the development of SSc, and a powerful indicator of severe skin and lung involvement in patients with SSc.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.110509","type":"journal-article","created":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T22:34:50Z","timestamp":1320186890000},"page":"106-111","source":"Crossref","is-referenced-by-count":16,"title":["Association Between Thr21Met and Ser89Asn Polymorphisms of the Urotensin II Gene and Systemic 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