{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T10:44:10Z","timestamp":1782470650649,"version":"3.54.5"},"reference-count":38,"publisher":"The Journal of Rheumatology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To examine whether IgG glycosylation changes and<jats:italic>MBL2<\/jats:italic>genotypes are associated with systemic inflammation and joint destruction in rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>IgG N-glycan content was determined from serum in 118 patients with RA by high-throughput glycan analysis using normal-phase high-pressure liquid chromatography.<jats:italic>MBL2<\/jats:italic>extended genotypes (YA\/YA, YA\/XA, XA\/XA, YA\/YO, XA\/YO, YO\/YO) were determined. Systemic inflammation was assessed by serum levels of C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor-\u03b1 (TNF-\u03b1). Joint destruction was assessed by total Sharp score (TSS) and alloplastic surgery records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>IgG hypogalactosylation was significantly correlated to IL-6 (Spearman\u2019s rho = 0.32, p &lt; 0.001), CRP (Spearman\u2019s rho = 0.31, p &lt; 0.001), TSS (Spearman\u2019s rho = 0.25, p = 0.01), and alloplastic replacement of joints (Spearman\u2019s rho = 0.18, p = 0.05). In multivariate analysis including age, CRP, anticitrullinated protein antibodies (ACPA), and other confounders, IgG hypogalactosylation was significantly associated with TSS (p = 0.014) and alloplastic joint replacement (OR 76.5, p = 0.041) in patients homozygous for the high expression<jats:italic>MBL2<\/jats:italic>genotype YA\/YA, but not in carriers of lower expression genotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Decreased galactosylation of IgG correlated to markers of inflammation, i.e., IL-6 and CRP. Only in patients homozygous for high expression of the<jats:italic>MBL2<\/jats:italic>genotype YA\/YA was IgG hypogalactosylation associated with markers of joint destruction. Our results suggest that inflammation-associated decreased galactosylation of IgG combined with high expression<jats:italic>MBL2<\/jats:italic>genotypes are involved in the pathophysiology of RA.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.110584","type":"journal-article","created":{"date-parts":[[2012,1,16]],"date-time":"2012-01-16T01:23:11Z","timestamp":1326676991000},"page":"463-469","source":"Crossref","is-referenced-by-count":37,"title":["IgG Glycosylation Changes and<i>MBL2<\/i>Polymorphisms: Associations with Markers of Systemic Inflammation and Joint Destruction in Rheumatoid Arthritis"],"prefix":"10.3899","volume":"39","author":[{"given":"LONE N.","family":"TROELSEN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00d8REN","family":"JACOBSEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JODIE L.","family":"ABRAHAMS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LOUISE","family":"ROYLE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PAULINE M.","family":"RUDD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EVA","family":"NARVESTAD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NIELS H.","family":"HEEGAARD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PETER","family":"GARRED","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2012,1,15]]},"reference":[{"key":"2018112909275578000_39.3.463.1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1740"},{"key":"2018112909275578000_39.3.463.2","first-page":"20","article-title":"Individual relationship between progression of radiological damage and the acute phase response in early rheumatoid arthritis. Towards development of a decision support system","volume":"24","author":"Van Leeuwen","year":"1997","journal-title":"J Rheumatol"},{"key":"2018112909275578000_39.3.463.3","doi-asserted-by":"publisher","DOI":"10.1002\/art.10167"},{"key":"2018112909275578000_39.3.463.4","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei203"},{"key":"2018112909275578000_39.3.463.5","doi-asserted-by":"publisher","DOI":"10.1002\/art.20316"},{"key":"2018112909275578000_39.3.463.6","doi-asserted-by":"publisher","DOI":"10.1038\/316452a0"},{"key":"2018112909275578000_39.3.463.7","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.5.1731"},{"key":"2018112909275578000_39.3.463.8","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018582930906"},{"key":"2018112909275578000_39.3.463.9","doi-asserted-by":"publisher","DOI":"10.1002\/art.27533"},{"key":"2018112909275578000_39.3.463.10","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0370-7"},{"key":"2018112909275578000_39.3.463.11","doi-asserted-by":"publisher","DOI":"10.3109\/07853899609033129"},{"key":"2018112909275578000_39.3.463.12","doi-asserted-by":"publisher","DOI":"10.1007\/s10719-006-5409-0"},{"key":"2018112909275578000_39.3.463.13","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/33.1.36"},{"key":"2018112909275578000_39.3.463.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(03)00104-4"},{"key":"2018112909275578000_39.3.463.15","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200003)43:3<515::AID-ANR6>3.0.CO;2-T"},{"key":"2018112909275578000_39.3.463.16","first-page":"935","article-title":"The influence of mannose binding lectin polymorphisms on disease outcome in early polyarthritis","volume":"28","author":"Jacobsen","year":"2001","journal-title":"J Rheumatol"},{"key":"2018112909275578000_39.3.463.17","first-page":"442","article-title":"Polymorphisms in the mannose binding lectin (MBL) gene are not associated with radiographic erosions in rheumatoid or inflammatory polyarthritis","volume":"31","author":"Barton","year":"2004","journal-title":"J Rheumatol"},{"key":"2018112909275578000_39.3.463.18","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken226"},{"key":"2018112909275578000_39.3.463.19","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080846"},{"key":"2018112909275578000_39.3.463.20","first-page":"1692","article-title":"Patients with rheumatoid arthritis have higher levels of mannan-binding lectin than their first-degree relatives and unrelated controls","volume":"34","author":"Saevarsdottir","year":"2007","journal-title":"J Rheumatol"},{"key":"2018112909275578000_39.3.463.21","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090812"},{"key":"2018112909275578000_39.3.463.22","doi-asserted-by":"publisher","DOI":"10.1038\/nm0395-237"},{"key":"2018112909275578000_39.3.463.23","doi-asserted-by":"publisher","DOI":"10.1002\/art.22302"},{"key":"2018112909275578000_39.3.463.24","first-page":"26","article-title":"Two edged role of mannose binding lectin in rheumatoid arthritis: A cross sectional study","volume":"27","author":"Garred","year":"2000","journal-title":"J Rheumatol"},{"key":"2018112909275578000_39.3.463.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2007.12.012"},{"key":"2018112909275578000_39.3.463.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2009.10.021"},{"key":"2018112909275578000_39.3.463.27","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"2018112909275578000_39.3.463.28","first-page":"261","article-title":"How to read radiographs according to the Sharp\/van der Heijde method","volume":"27","author":"van der Heijde","year":"2000","journal-title":"J Rheumatol"},{"key":"2018112909275578000_39.3.463.29","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn090"},{"key":"2018112909275578000_39.3.463.30","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.4049\/jimmunol.155.6.3013","article-title":"Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein","volume":"155","author":"Madsen","year":"1995","journal-title":"J Immunol"},{"key":"2018112909275578000_39.3.463.31","doi-asserted-by":"publisher","DOI":"10.1126\/science.1131712"},{"key":"2018112909275578000_39.3.463.32","doi-asserted-by":"publisher","DOI":"10.1126\/science.1129594"},{"key":"2018112909275578000_39.3.463.33","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(99)00060-0"},{"key":"2018112909275578000_39.3.463.34","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.1998.018"},{"key":"2018112909275578000_39.3.463.35","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202069200"},{"key":"2018112909275578000_39.3.463.36","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01864.x"},{"key":"2018112909275578000_39.3.463.37","first-page":"1531","article-title":"Characterization of changes in IgG associated oligosaccharide profiles in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis using fluorophore linked carbohydrate electrophoresis","volume":"28","author":"Martin","year":"2001","journal-title":"J Rheumatol"},{"key":"2018112909275578000_39.3.463.38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01699.x"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.110584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T15:40:41Z","timestamp":1686670841000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.110584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,15]]},"references-count":38,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,3,1]]},"published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.3899\/jrheum.110584"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.110584","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,15]]}}}