{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:12:31Z","timestamp":1789002751858,"version":"build-2803163510"},"reference-count":15,"publisher":"The Journal of Rheumatology","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To study the clinical course and outcome of fetal sinus bradycardia (SB) due to maternal antibody-induced sinus node dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We reviewed the maternal, prenatal, and postnatal findings of fetuses with SB associated with elevated maternal anti-SSA\/Ro and anti-SSB\/La antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Of the 6 cases diagnosed prenatally, 3 had isolated SB persisting after birth and had a good prognosis. Three fetuses with SB and severe myocardial involvement (congenital complete heart block and\/or endocardial fibroelastosis) succumbed <jats:italic>in utero<\/jats:italic> in spite of treatment. Postmortem histopathology in 1 fetus showed inflammatory destruction of the sinus and atrioventricular nodes. SB was detected incidentally in a 7-year-old girl. She had intermittent heart block with progressive sinus arrest requiring permanent pacemaker.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Fetal SB associated with maternal autoantibodies may persist in childhood, with a good prognosis in the absence of widespread cardiac involvement.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.110720","type":"journal-article","created":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T11:52:17Z","timestamp":1321444337000},"page":"2682-2685","source":"Crossref","is-referenced-by-count":25,"title":["Persistent Fetal Sinus Bradycardia Associated with Maternal Anti-SSA\/Ro and Anti-SSB\/La Antibodies"],"prefix":"10.3899","volume":"38","author":[{"given":"PRIYA","family":"CHOCKALINGAM","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EDGAR T.","family":"JAEGGI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LUKAS A.","family":"RAMMELOO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MONIQUE C.","family":"HAAK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PHEBE N.","family":"ADAMA van SCHELTEMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOHANNES M.P.J.","family":"BREUR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARGOT M.","family":"BARTELINGS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SALLY-ANN B.","family":"CLUR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NICO A.","family":"BLOM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2011,11,15]]},"reference":[{"key":"2018112909271685000_38.12.2682.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00161-2"},{"key":"2018112909271685000_38.12.2682.2","doi-asserted-by":"publisher","DOI":"10.1186\/ar1690"},{"key":"2018112909271685000_38.12.2682.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000121566.01778.06"},{"key":"2018112909271685000_38.12.2682.4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.517326"},{"key":"2018112909271685000_38.12.2682.5","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90064-0"},{"key":"2018112909271685000_38.12.2682.6","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1056\/NEJM198501103120206","article-title":"Maternal connective tissue disease and congenital heart block. 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