{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:14:21Z","timestamp":1780082061813,"version":"3.54.0"},"reference-count":50,"publisher":"The Journal of Rheumatology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>In pigmented villonodular synovitis (PVNS), some cases recur and progress to osteochondral destruction. The aim of our study was to clarify the occurrence of osteochondral destruction according to the location of PVNS during the clinical course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Seventy-two patients with PVNS (43 female, 29 male) with a mean age of 40 years (range 3\u201387 yrs) had been referred to our institutions. Factors influencing the occurrence of osteochondral destruction were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Mean followup was 60 months (range 12\u2013190 mo). Adjacent bone change occurred in 24 (42%) of 57 patients, who were evaluated at the time of the first consultation. Eight (89%) of 9 patients with hip lesions initially had bone lesions, significantly more frequently than those with other lesions (p = 0.038). Duration of symptoms was significantly correlated with the occurrence of bone lesions in diffuse knee lesions (p = 0.005). During followup, patients with location in the knee had a significantly higher incidence of osteoarthritic change (73%) compared to those with foot and ankle involvement (p = 0.027). Re-operation was more frequently required for knee lesions due to the high recurrence rate (32%). Patients who required re-operation had significantly more marked osteoarthritic change in knees (p = 0.001) during followup than those who did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>For PVNS arising in knees, repeated recurrences followed by re-operation resulted in the progression of osteoarthritic change. PVNS arising in hips, feet, and ankles developed bone lesions initially, probably due to the limited volume of these joints. The indications for re-operation for recurrent knee lesions require careful consideration regarding progression of osteoarthritic change.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.110730","type":"journal-article","created":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T06:25:32Z","timestamp":1324016732000},"page":"345-351","source":"Crossref","is-referenced-by-count":26,"title":["Osteochondral Destruction in Pigmented Villonodular Synovitis During the Clinical Course"],"prefix":"10.3899","volume":"39","author":[{"given":"YOSHIHIRO","family":"NISHIDA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SATOSHI","family":"TSUKUSHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIROATSU","family":"NAKASHIMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIDESHI","family":"SUGIURA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOSHIHISA","family":"YAMADA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIROSHI","family":"URAKAWA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EISUKE","family":"ARAI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NAOKI","family":"ISHIGURO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2011,12,15]]},"reference":[{"key":"2018112909272970000_39.2.345.1","first-page":"731","article-title":"Pigmented villonodular synovitis, bursitis and tenosynovitis. A discussion of the synovial and bursal equivalents of the tenosynovial lesion commonly denoted as xanthanoma, xanthogranuloma, giant cell tumor or myeloplaxoma of the tendon sheath, with some considerations of this tendon sheath lesion itself","volume":"31","author":"Jaffe","year":"1941","journal-title":"Arch Pathol"},{"key":"2018112909272970000_39.2.345.2","doi-asserted-by":"crossref","first-page":"122","DOI":"10.2106\/00004623-196749010-00010","article-title":"Localized pigmented villonodular synovitis of the knee: report of five cases","volume":"49A","author":"Granowitz","year":"1967","journal-title":"J Bone Joint Surg"},{"key":"2018112909272970000_39.2.345.3","first-page":"576","article-title":"Analysis of 35 cases of localized and diffuse tenosynovial giant cell tumor: A report from the Chromosomes and Morphology (CHAMP) study group","volume":"12","author":"Sciot","year":"1999","journal-title":"Mod Pathol"},{"key":"2018112909272970000_39.2.345.4","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/00005792-198005000-00004","article-title":"Pigmented villonodular synovitis and tenosynovitis: A clinical epidemiologic study of 166 cases and literature review","volume":"59","author":"Myers","year":"1980","journal-title":"Medicine"},{"key":"2018112909272970000_39.2.345.5","doi-asserted-by":"publisher","DOI":"10.1007\/BF02425936"},{"key":"2018112909272970000_39.2.345.6","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200107000-00026"},{"key":"2018112909272970000_39.2.345.7","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.C.01297"},{"key":"2018112909272970000_39.2.345.8","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1177\/107110079902000512","article-title":"Pigmented villonodular synovitis of the foot and ankle: A review of six cases","volume":"20","author":"Ghert","year":"1999","journal-title":"Foot Ankle Int"},{"key":"2018112909272970000_39.2.345.9","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1177\/107110079902000909","article-title":"Pigmented villonodular synovitis of the foot and ankle: A report of eight cases","volume":"20","author":"Rochwerger","year":"1999","journal-title":"Foot Ankle Int"},{"key":"2018112909272970000_39.2.345.10","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.2106\/00004623-200212000-00011","article-title":"Treatment of advanced primary and recurrent diffuse pigmented villonodular synovitis of the knee","volume":"84","author":"Chin","year":"2002","journal-title":"J Bone Joint Surg Am"},{"key":"2018112909272970000_39.2.345.11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00003086-199403000-00024","article-title":"Surgical treatment of diffuse pigmented villonodular synovitis of the knee","volume":"300","author":"Flandry","year":"1994","journal-title":"Clin Orthop Relat Res"},{"key":"2018112909272970000_39.2.345.12","first-page":"335","article-title":"The pathogenesis and long-term end results of pigmented villonodular synovitis","volume":"114","author":"Granowitz","year":"1976","journal-title":"Clin Orthop Relat Res"},{"key":"2018112909272970000_39.2.345.13","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/00003086-198203000-00023","article-title":"Pigmented villonodular synovitis of joints","volume":"163","author":"Johansson","year":"1982","journal-title":"Clin Orthop Relat Res"},{"key":"2018112909272970000_39.2.345.14","doi-asserted-by":"crossref","first-page":"76","DOI":"10.2106\/00004623-198466010-00012","article-title":"Pigmented villonodular synovitis (giant-cell tumor of the tendon sheath and synovial membrane). A review of eighty-one cases","volume":"66","author":"Rao","year":"1984","journal-title":"J Bone Joint Surg Am"},{"key":"2018112909272970000_39.2.345.15","doi-asserted-by":"crossref","first-page":"76","DOI":"10.2106\/00004623-199801000-00013","article-title":"Total knee arthroplasty in patients who have pigmented villonodular synovitis","volume":"80","author":"Hamlin","year":"1998","journal-title":"J Bone Joint Surg Am"},{"key":"2018112909272970000_39.2.345.16","doi-asserted-by":"publisher","DOI":"10.1136\/ard.16.4.494"},{"key":"2018112909272970000_39.2.345.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2010.07.005"},{"key":"2018112909272970000_39.2.345.18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1302\/0301-620X.50B2.290","article-title":"The diagnosis and treatment of pigmented villonodular synovitis","volume":"50","author":"Byers","year":"1968","journal-title":"J Bone Joint Surg Br"},{"key":"2018112909272970000_39.2.345.19","first-page":"1620","article-title":"Pigmented villonodular synovitis. Review of 20 cases","volume":"28","author":"Durr","year":"2001","journal-title":"J Rheumatol"},{"key":"2018112909272970000_39.2.345.20","doi-asserted-by":"crossref","first-page":"76","DOI":"10.2106\/00004623-196951010-00005","article-title":"Fibrous xanthoma of synovium (giant-cell tumor of tendon sheath, pigmented nodular synovitis). A study of one hundred and eighteen cases","volume":"51","author":"Jones","year":"1969","journal-title":"J Bone Joint Surg Am"},{"key":"2018112909272970000_39.2.345.21","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-1040(06)75830-5"},{"key":"2018112909272970000_39.2.345.22","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/00003086-198910000-00034","article-title":"Pigmented villonodular synovitis. A retrospective review of affected large joints","volume":"247","author":"Schwartz","year":"1989","journal-title":"Clin Orthop Relat Res"},{"key":"2018112909272970000_39.2.345.23","doi-asserted-by":"publisher","DOI":"10.1136\/ard.50.12.917"},{"key":"2018112909272970000_39.2.345.24","doi-asserted-by":"publisher","DOI":"10.3109\/03009748609092587"},{"key":"2018112909272970000_39.2.345.25","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5413.45326"},{"key":"2018112909272970000_39.2.345.26","doi-asserted-by":"publisher","DOI":"10.1186\/1749-799X-4-8"},{"key":"2018112909272970000_39.2.345.27","doi-asserted-by":"crossref","first-page":"877","DOI":"10.2214\/ajr.143.4.877","article-title":"Pigmented villonodular synovitis of synovial joints: Clinical, pathologic, and radiologic features","volume":"143","author":"Dorwart","year":"1984","journal-title":"AJR Am J Roentgenol"},{"key":"2018112909272970000_39.2.345.28","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1302\/0301-620X.50B2.306","article-title":"Bone lesions in pigmented villonodular synovitis","volume":"50","author":"Scott","year":"1968","journal-title":"J Bone Joint Surg Br"},{"key":"2018112909272970000_39.2.345.29","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/S0749-8063(03)00127-0","article-title":"Result of arthroscopic treatment of pigmented villonodular synovitis of the knee","volume":"19","author":"De Ponti","year":"2003","journal-title":"Arthroscopy"},{"key":"2018112909272970000_39.2.345.30","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2106\/00004623-199274010-00015","article-title":"Pigmented villonodular synovitis of the knee. The results of total arthroscopic synovectomy, partial, arthroscopic synovectomy, and arthroscopic local excision","volume":"74","author":"Ogilvie-Harris","year":"1992","journal-title":"J Bone Joint Surg Am"},{"key":"2018112909272970000_39.2.345.31","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200010000-00026"},{"key":"2018112909272970000_39.2.345.32","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1053\/ar.1999.v15.015061","article-title":"Arthroscopic treatment of pigmented villonodular synovitis of the knee","volume":"15","author":"Zvijac","year":"1999","journal-title":"Arthroscopy"},{"key":"2018112909272970000_39.2.345.33","doi-asserted-by":"publisher","DOI":"10.1053\/jars.2001.24068"},{"key":"2018112909272970000_39.2.345.34","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/00003086-199110000-00030","article-title":"Localized pigmented villonodular synovitis of the knee. Arthroscopic treatment","volume":"271","author":"Moskovich","year":"1991","journal-title":"Clin Orthop Relat Res"},{"key":"2018112909272970000_39.2.345.35","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.10.1113"},{"key":"2018112909272970000_39.2.345.36","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-0922-7"},{"key":"2018112909272970000_39.2.345.37","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00003086-198907000-00004","article-title":"Magnetic resonance imaging of the musculoskeletal system. An overview","volume":"244","author":"Bassett","year":"1989","journal-title":"Clin Orthop Relat Res"},{"key":"2018112909272970000_39.2.345.38","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/00003086-198806000-00019","article-title":"The use of MRI to assist in diagnosis of pigmented villonodular synovitis of the knee joint","volume":"231","author":"Mandelbaum","year":"1988","journal-title":"Clin Orthop Relat Res"},{"key":"2018112909272970000_39.2.345.39","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/0749-8063(95)90205-8","article-title":"Localized pigmented villonodular synovitis of the posterior compartment of the knee: Diagnosis with magnetic resonance imaging","volume":"11","author":"Muscolo","year":"1995","journal-title":"Arthroscopy"},{"key":"2018112909272970000_39.2.345.40","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3928\/0147-7447-19900201-08","article-title":"The use of magnetic resonance imaging in the diagnosis of pigmented villonodular synovitis","volume":"13","author":"Poletti","year":"1990","journal-title":"Orthopedics"},{"key":"2018112909272970000_39.2.345.41","doi-asserted-by":"publisher","DOI":"10.1016\/0899-7071(89)90064-8"},{"key":"2018112909272970000_39.2.345.42","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2106\/00004623-196547020-00006","article-title":"Diffuse pigmented villonodular synovitis of the hip joint. Review of the literature and report of four cases","volume":"47","author":"Chung","year":"1965","journal-title":"J Bone Joint Surg Am"},{"key":"2018112909272970000_39.2.345.43","first-page":"110","article-title":"Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in pigmented villonodular synovitis suggests their potential role for joint destruction","volume":"31","author":"Uchibori","year":"2004","journal-title":"J Rheumatol"},{"key":"2018112909272970000_39.2.345.44","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.ijrobp.2006.10.016","article-title":"External beam radiotherapy as postoperative treatment of diffuse pigmented villonodular synovitis","volume":"67","author":"Berger","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2018112909272970000_39.2.345.45","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000239142.48188.f6"},{"key":"2018112909272970000_39.2.345.46","doi-asserted-by":"publisher","DOI":"10.1007\/s11420-008-9104-5"},{"key":"2018112909272970000_39.2.345.47","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00514-Y"},{"key":"2018112909272970000_39.2.345.48","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000229345.57092.a2"},{"key":"2018112909272970000_39.2.345.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2006.10.014"},{"key":"2018112909272970000_39.2.345.50","first-page":"19","article-title":"Irradiation therapy of pigmented villonodular synovitis","volume":"18","author":"Friedman","year":"1957","journal-title":"Bull Hosp Joint Dis"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.110730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,11]],"date-time":"2023-06-11T22:01:15Z","timestamp":1686520875000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.110730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,15]]},"references-count":50,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2,1]]},"published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.3899\/jrheum.110730"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.110730","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,15]]}}}