{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:32:12Z","timestamp":1791055932440,"version":"4.1.0"},"reference-count":17,"publisher":"The Journal of Rheumatology","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>We studied the effects of intravenous immunoglobulin (IVIG) treatment on clinical symptoms and regulatory T (Treg) cell frequency in patients with eosinophilic granulomatosis with polyangiitis (EGPA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Twenty-two EGPA patients with severe mononeuritis multiplex or cardiac dysfunction received IVIG therapy combined with conventional therapy (corticosteroid, immunosuppressants, or both). As a control, 24 EGPA patients without severe vasculitic symptoms were treated with conventional therapy. Before, during, and after treatment, we determined percentages of Treg cells and other relevant cells in patients\u2019 peripheral blood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>The frequency of CD25+ among CD4+ T cells was lower at onset in the study group than in controls but increased significantly after IVIG treatment, relative to controls. The frequency of CD25+ among CD4+ T cells correlated with the frequency of FOXP3+ among CD4+ T cells and interleukin 10 produced by CD25+CD4+ T cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>The increase in Treg cells seen with the combination of IVIG and conventional therapy may promote remission in EGPA.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.110981","type":"journal-article","created":{"date-parts":[[2012,4,2]],"date-time":"2012-04-02T00:15:04Z","timestamp":1333325704000},"page":"1019-1025","source":"Crossref","is-referenced-by-count":46,"title":["High-dose Intravenous Immunoglobulin Treatment Increases Regulatory T Cells in Patients with Eosinophilic Granulomatosis with Polyangiitis"],"prefix":"10.3899","volume":"39","author":[{"given":"NAOMI","family":"TSURIKISAWA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIROSHI","family":"SAITO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHIYAKO","family":"OSHIKATA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TAKAHIRO","family":"TSUBURAI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KAZUO","family":"AKIYAMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2012,4,1]]},"reference":[{"key":"2018112909274918000_39.5.1019.1","first-page":"277","article-title":"Allergic granulomatosis, allergic angiitis, and periarteritis nodosa","volume":"27","author":"Churg","year":"1951","journal-title":"Am J Pathol"},{"key":"2018112909274918000_39.5.1019.2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199601000-00003"},{"key":"2018112909274918000_39.5.1019.3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1365-2249.1995.tb02268.x","article-title":"Treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis with high-dose intravenous immunoglobulin","volume":"101","author":"Richter","year":"1995","journal-title":"Clin Exp Immunol"},{"key":"2018112909274918000_39.5.1019.4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/14.12.1712"},{"key":"2018112909274918000_39.5.1019.5","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S1081-1206(10)61714-0","article-title":"Treatment of Churg-Strauss syndrome with high-dose intravenous immunoglobulin","volume":"92","author":"Tsurikisawa","year":"2004","journal-title":"Ann Allerg Asthma Immunol"},{"key":"2018112909274918000_39.5.1019.6","doi-asserted-by":"publisher","DOI":"10.1038\/nri2138"},{"key":"2018112909274918000_39.5.1019.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.05.040"},{"key":"2018112909274918000_39.5.1019.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra993360"},{"key":"2018112909274918000_39.5.1019.9","doi-asserted-by":"crossref","unstructured":"Maddur MS Othy S Hegde P Vani J Lacroix-Desmazes S Bayry J Immunomodulation by intravenous immunoglobulin: Role of regulatory T cells. 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