{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:04:56Z","timestamp":1761609896248},"reference-count":50,"publisher":"The Journal of Rheumatology","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Rheumatic diseases cause significant morbidity within American Indian populations. Clinical disease presentations, as well as historically associated autoantibodies, are not always useful in making a rapid diagnosis or assessing prognosis. The purpose of our study was to identify autoantibody associations among Oklahoma tribal populations with rheumatic disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Oklahoma tribal members (110 patients with rheumatic disease and 110 controls) were enrolled at tribal-based clinics. Patients with rheumatic disease (suspected or confirmed diagnosis) were assessed by a rheumatologist for clinical features, disease criteria, and activity measures. Blood samples were collected and tested for common rheumatic disease autoantibodies [antinuclear antibody (ANA), anti-cyclic citrullinated peptide antibodies (anti-CCP), rheumatoid factor (RF), anti-Ro, anti-La, anti-Sm, anti-nRNP, anti-ribosomal P, anti-dsDNA, and anticardiolipins].<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>In patients with suspected systemic rheumatic diseases, 72% satisfied American College of Rheumatology classification criteria: 40 (36%) had rheumatoid arthritis (RA), 16 (15%) systemic lupus erythematosus, 8 (7%) scleroderma, 8 (7%) osteoarthritis, 4 (4%) fibromyalgia, 2 (2%) seronegative spondyloarthropathy, 1 Sj\u00f6gren\u2019s syndrome, and 1 sarcoidosis. Compared to controls, RA patient sera were more likely to contain anti-CCP (55% vs 2%; p &lt; 0.001) or RF IgM antibodies (57% vs 10%; p &lt; 0.001); however, the difference was greater for anti-CCP. Anti-CCP positivity conferred higher disease activity scores (DAS28 5.6 vs 4.45; p = 0.021) while RF positivity did not (DAS28 5.36 vs 4.64; p = 0.15). Anticardiolipin antibodies (25% of rheumatic disease patients vs 10% of controls; p = 0.0022) and ANA (63% vs 21%; p &lt; 0.0001) were more common in rheumatic disease patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Anti-CCP may serve as a more specific RA biomarker in American Indian patients, while the clinical significance of increased frequency of anticardiolipin antibodies needs further evaluation.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.110984","type":"journal-article","created":{"date-parts":[[2012,8,16]],"date-time":"2012-08-16T00:37:23Z","timestamp":1345077443000},"page":"1934-1941","source":"Crossref","is-referenced-by-count":15,"title":["Rheumatic Disease Among Oklahoma Tribal Populations: A Cross-sectional Study"],"prefix":"10.3899","volume":"39","author":[{"given":"JASMINE R.","family":"GADDY","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EVAN S.","family":"VISTA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JULIE M.","family":"ROBERTSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AMY B.","family":"DEDEKE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VIRGINIA C.","family":"ROBERTS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WENDY S.","family":"KLEIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEREMY H.","family":"LEVIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FABIO H.","family":"MOTA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TINA M.","family":"COOPER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GLORIA A.","family":"GRIM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SOHAIL","family":"KHAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JUDITH A.","family":"JAMES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2012,8,15]]},"reference":[{"key":"2018112909282088000_39.10.1934.1","first-page":"309","article-title":"Incidence patterns of immunogenetic diseases in the North American Indians","volume":"7","author":"Acers","year":"1994","journal-title":"J Okla State Med Assoc"},{"key":"2018112909282088000_39.10.1934.2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-5-30"},{"key":"2018112909282088000_39.10.1934.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(99)80003-1"},{"key":"2018112909282088000_39.10.1934.4","first-page":"1884","article-title":"Systemic lupus erythematosus in North American Indians: A population based study","volume":"27","author":"Peschken","year":"2000","journal-title":"J Rheumatol"},{"key":"2018112909282088000_39.10.1934.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2004.08.003"},{"key":"2018112909282088000_39.10.1934.6","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390216"},{"key":"2018112909282088000_39.10.1934.7","unstructured":"State and County QuickFacts. 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