{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:30:04Z","timestamp":1790166604493,"version":"4.1.0"},"reference-count":44,"publisher":"The Journal of Rheumatology","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To analyze the role of interleukin 22 (IL-22) in rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>IL-22 serum levels were measured in 83 patients with established RA under treatment with disease-modifying antirheumatic drugs and in 30 healthy controls matched for age and sex. Patients were assessed for clinical and laboratory variables. Correlations of IL-22 serum levels with disease activity measures [Clinical Disease Activity Index (CDAI) and Disease Activity Score for 28 joints (DAS28)], serological markers, bone erosions, and demographic factors were assessed. Peripheral blood mononuclear cells (PBMC) from 30 patients with RA and 14 controls were purified and stimulated<jats:italic>in vitro<\/jats:italic>with phorbol myristate acetate (PMA)\/ionomycin. IL-22 production by PBMC and in serum was investigated by ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>IL-22 levels were increased in patients with RA compared with controls (mean 432.37 pg\/ml and 67.45 pg\/ml, respectively; p &lt; 0.001). Levels of IL-22 correlated with DAS28 and CDAI measures. Rheumatoid factor (RF) positivity was correlated with higher levels of IL-22 in patients with RA (mean 575.08 pg\/ml; p = 0.001). The presence of bone erosions was associated with high IL-22 levels (p = 0.0001). PBMC stimulated with PMA\/ionomycin expressed higher levels of IL-22 in patients with RA than controls but this was not significant (mean 584.75 pg\/ml and 295.57 pg\/ml; p = 0.553).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>IL-22 is elevated in the serum of patients with established RA. Elevated serum IL-22 allows discrimination between patients with different clinical and laboratory measures and indicates the potential of IL-22 as an additional tool for assessment of activity in RA, particularly in patients with RF antibodies and longterm disease. IL-22 is associated with bone-destructive disease.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.111027","type":"journal-article","created":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T00:34:02Z","timestamp":1337128442000},"page":"1320-1325","source":"Crossref","is-referenced-by-count":76,"title":["Increased Serum Interleukin 22 in Patients with Rheumatoid Arthritis and Correlation with Disease Activity"],"prefix":"10.3899","volume":"39","author":[{"suffix":"Jr","given":"LAURINDO FERREIRA","family":"da ROCHA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c2NGELA LUZIA BRANCO PINTO","family":"DUARTE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANDR\u00c9A TAVARES","family":"DANTAS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HENRIQUE ATA\u00cdDE","family":"MARIZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IVAN da ROCHA","family":"PITTA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SUELY LINS","family":"GALDINO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MAIRA GALDINO da ROCHA","family":"PITTA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2012,5,15]]},"reference":[{"key":"2018112909280233000_39.7.1320.1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c2210"},{"key":"2018112909280233000_39.7.1320.2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2094"},{"key":"2018112909280233000_39.7.1320.3","doi-asserted-by":"publisher","DOI":"10.1038\/nature01661"},{"key":"2018112909280233000_39.7.1320.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2007.09.014"},{"key":"2018112909280233000_39.7.1320.5","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem203"},{"key":"2018112909280233000_39.7.1320.6","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030896"},{"key":"2018112909280233000_39.7.1320.7","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062259"},{"key":"2018112909280233000_39.7.1320.8","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.9.5652"},{"key":"2018112909280233000_39.7.1320.9","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1610"},{"key":"2018112909280233000_39.7.1320.10","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1613"},{"key":"2018112909280233000_39.7.1320.11","doi-asserted-by":"publisher","DOI":"10.1038\/nri2586"},{"key":"2018112909280233000_39.7.1320.12","doi-asserted-by":"publisher","DOI":"10.1038\/nature09447"},{"key":"2018112909280233000_39.7.1320.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2006.09.001"},{"key":"2018112909280233000_39.7.1320.14","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxr001"},{"key":"2018112909280233000_39.7.1320.15","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005304200"},{"key":"2018112909280233000_39.7.1320.16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007837200"},{"key":"2018112909280233000_39.7.1320.17","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061308"},{"key":"2018112909280233000_39.7.1320.18","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.06.071"},{"key":"2018112909280233000_39.7.1320.19","doi-asserted-by":"publisher","DOI":"10.1002\/art.20965"},{"key":"2018112909280233000_39.7.1320.20","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.152074"},{"key":"2018112909280233000_39.7.1320.21","doi-asserted-by":"publisher","DOI":"10.1002\/art.24568"},{"key":"2018112909280233000_39.7.1320.22","doi-asserted-by":"crossref","unstructured":"Shen H Goodall JC Gaston JS . 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