{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:38:36Z","timestamp":1790890716353,"version":"4.1.0"},"reference-count":28,"publisher":"The Journal of Rheumatology","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Ankylosing spondylitis (AS) is generally observed in young patients but can occur later in life or in persons \u2265 50 years of age. Our objective was to characterize the clinical features of late-onset AS in a large multicenter national cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We studied late-onset AS in the National Registry of Spondyloarthritis of the Spanish Society of Rheumatology (REGISPONSER database) cohort (n = 1257), of whom 3.5% had onset at age \u2265 50 years versus a control group with onset at &lt; 50 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>There were no differences between late-onset and early-onset AS according to sex and family history of spondyloarthropathies. Patients in the late-onset group more often showed involvement of the cervical spine (22.7% vs 9.7%; p = 0.03) and arthritis of the upper (13.6% vs 3.0%; p = 0.002) and lower limbs (27.3% vs 15.2%; p = 0.03) as first manifestations than did patients in the early-onset group. A higher percentage of mixed forms (axial and peripheral joint disease) during the course of the disease was also recorded in the late-onset group (50% vs 24%; p = 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Our study suggests that age at onset of AS affects the patients\u2019 presenting clinical form. Arthritis of the upper limbs requires a differential diagnosis with other conditions frequent in patients over 50 years of age, such as rheumatoid arthritis or crystal-induced arthropathy.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.111082","type":"journal-article","created":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T21:38:57Z","timestamp":1331847537000},"page":"1008-1012","source":"Crossref","is-referenced-by-count":48,"title":["Clinical Features of Late-onset Ankylosing Spondylitis: Comparison with Early-onset Disease"],"prefix":"10.3899","volume":"39","author":[{"given":"CARLOS","family":"MONTILLA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JAVIER","family":"DEL PINO-MONTES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EDUARDO","family":"COLLANTES-ESTEVEZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PILAR","family":"FONT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PEDRO","family":"ZARCO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUAN","family":"MULERO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JORDI","family":"GRATAC\u00d3S","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CARLOS","family":"RODR\u00cdGUEZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XAVIER","family":"JUANOLA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOSE LUIS","family":"FERN\u00c1NDEZ-SUEIRO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RAQUEL","family":"ALMODOVAR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the REGISPONSER Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2012,3,15]]},"reference":[{"key":"2018112909274903000_39.5.1008.1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)91109-4"},{"key":"2018112909274903000_39.5.1008.2","first-page":"182","article-title":"Systemic lupus erythematosus in the elderly","volume":"14","author":"Maddison","year":"1987","journal-title":"J Rheumatol Suppl"},{"key":"2018112909274903000_39.5.1008.3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00005792-199303000-00005","article-title":"Systemic lupus erythematosus: Clinical and immunologic patterns of disease expression in a cohort of 1,000 patients","volume":"72","author":"Cervera","year":"1993","journal-title":"Medicine"},{"issue":"Suppl 20","key":"2018112909274903000_39.5.1008.4","first-page":"S49","article-title":"Elderly onset rheumatoid arthritis: Clinical aspects","volume":"4","author":"Bajocchi","year":"2000","journal-title":"Clin Exp Rheumatol"},{"key":"2018112909274903000_39.5.1008.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2010.06.003"},{"key":"2018112909274903000_39.5.1008.6","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200522060-00001"},{"key":"2018112909274903000_39.5.1008.7","first-page":"2853","article-title":"Spondyloarthropathies","volume":"15","author":"Kataria","year":"2004","journal-title":"Am Fam Physician"},{"key":"2018112909274903000_39.5.1008.8","doi-asserted-by":"publisher","DOI":"10.1136\/ard.56.3.176"},{"key":"2018112909274903000_39.5.1008.9","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/30.1.69"},{"key":"2018112909274903000_39.5.1008.10","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-007-0331-8"},{"key":"2018112909274903000_39.5.1008.11","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-007-0483-6"},{"key":"2018112909274903000_39.5.1008.12","doi-asserted-by":"publisher","DOI":"10.1016\/S1297-319X(03)00041-1"},{"key":"2018112909274903000_39.5.1008.13","doi-asserted-by":"publisher","DOI":"10.2165\/11315970-000000000-00000"},{"key":"2018112909274903000_39.5.1008.14","doi-asserted-by":"publisher","DOI":"10.1136\/ard.41.6.574"},{"key":"2018112909274903000_39.5.1008.15","first-page":"1214","article-title":"Late onset peripheral spondyloarthropathy","volume":"16","author":"Dubost","year":"1989","journal-title":"J Rheumatol"},{"key":"2018112909274903000_39.5.1008.16","doi-asserted-by":"crossref","unstructured":"Ariza R Grupo de Estudio de Espondiloartropat\u00edas de la SER (GRESSER) . 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