{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:24:43Z","timestamp":1761863083841},"reference-count":23,"publisher":"The Journal of Rheumatology","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To determine the significance of hepatitis B virus (HBV)-associated antigen deposition in renal tissue from patients with systemic lupus erythematosus (SLE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>The medical records of 166 inpatients with lupus nephritis and 384 controls without SLE were analyzed retrospectively. Patients with SLE were classified as positive or negative depending on whether HBV-associated antigen deposition was detected in renal biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>HBV-associated antigen deposition was mainly detected in renal tissue from patients with SLE (50.6%), primary renal glomerular disease (20.8%), and allergic purpura (21.7%). It was not detected in renal tissue from patients with diabetic nephropathy, hypertensive nephrosclerosis, thin basement membrane nephropathy, or Alport syndrome. Hepatitis B surface antigen and core antigen were deposited in the mesangial region and vascular loops. The positive group had a significantly higher frequency of IgG, IgA, and IgM deposition than the negative group (53.6% vs 30.5%; p &lt; 0.01). There was no significant difference in the types of lupus nephritis observed between the 2 groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>There was a high prevalence of HBV-associated antigen deposition in renal tissue of patients with SLE by indirect immunofluorescence, which may result mainly from the cross-reactivity with deposited immunoglobulins.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.111107","type":"journal-article","created":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T01:38:57Z","timestamp":1331861937000},"page":"974-978","source":"Crossref","is-referenced-by-count":10,"title":["Hepatitis B Virus-associated Antigen Deposition in Renal Tissue from Patients with Systemic Lupus Erythematosus"],"prefix":"10.3899","volume":"39","author":[{"given":"ZHUOLONG","family":"WANG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MENGTAO","family":"LI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XIAOFENG","family":"ZENG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XINJIAN","family":"LIU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2012,3,15]]},"reference":[{"key":"2018112909274911000_39.5.974.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071297"},{"key":"2018112909274911000_39.5.974.2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22881"},{"key":"2018112909274911000_39.5.974.3","first-page":"655","article-title":"A study on the sero-epidemiology of hepatitis B in Chinese population aged over 3-years old [Chinese]","volume":"26","author":"Liang","year":"2005","journal-title":"Zhonghua Liu Xing Bin Xue Za Zhi"},{"key":"2018112909274911000_39.5.974.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1188-9"},{"key":"2018112909274911000_39.5.974.5","first-page":"325","article-title":"Hepatitis B virus infection in patients with systemic lupus erythematosus","volume":"34","author":"Chng","year":"1993","journal-title":"Singapore Med J"},{"key":"2018112909274911000_39.5.974.6","doi-asserted-by":"publisher","DOI":"10.1177\/096120339700600612"},{"key":"2018112909274911000_39.5.974.7","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780170512"},{"key":"2018112909274911000_39.5.974.8","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-007-8013-6"},{"key":"2018112909274911000_39.5.974.9","doi-asserted-by":"publisher","DOI":"10.1136\/ard.41.5.479"},{"key":"2018112909274911000_39.5.974.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.06.008"},{"key":"2018112909274911000_39.5.974.11","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ajcp\/88.4.412","article-title":"Hepatitis B virus-related glomerulopathy in patients with systemic lupus erythematosus","volume":"88","author":"Mac-Moune Lai","year":"1987","journal-title":"Am J Clin Pathol"},{"key":"2018112909274911000_39.5.974.12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1982.tb02711.x"},{"key":"2018112909274911000_39.5.974.13","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"2018112909274911000_39.5.974.14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra031087"},{"key":"2018112909274911000_39.5.974.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(05)80407-6"},{"key":"2018112909274911000_39.5.974.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.07.012"},{"key":"2018112909274911000_39.5.974.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2004.10.002"},{"key":"2018112909274911000_39.5.974.18","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-005-0357-8"},{"key":"2018112909274911000_39.5.974.19","doi-asserted-by":"publisher","DOI":"10.1159\/000077065"},{"key":"2018112909274911000_39.5.974.20","doi-asserted-by":"publisher","DOI":"10.1159\/000187144"},{"key":"2018112909274911000_39.5.974.21","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1038\/ki.1996.519","article-title":"Detection of hepatitis B virus DNA and RNA in kidney of HBV related glomerulonephritis","volume":"50","author":"Lai","year":"1996","journal-title":"Kidney Int"},{"key":"2018112909274911000_39.5.974.22","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20575"},{"key":"2018112909274911000_39.5.974.23","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880031"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.111107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T18:11:28Z","timestamp":1543515088000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.111107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,15]]},"references-count":23,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,5,1]]},"published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.3899\/jrheum.111107"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.111107","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,15]]}}}