{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:26:31Z","timestamp":1789943191247,"version":"4.0.1"},"reference-count":27,"publisher":"The Journal of Rheumatology","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To determine whether levels of plasma-soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) are elevated in patients with rheumatoid arthritis (RA) and whether levels are correlated with disease activity and other variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Our study included 71 patients with RA and 50 age- and sex-matched healthy controls. Clinical characteristics and laboratory measures, including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and 28-joint Disease Activity Score (DAS28) were assessed. Plasma levels of sTREM-1 and tumor necrosis factor-\u03b1 (TNF-\u03b1) were measured by ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Patients with RA had significantly higher plasma sTREM-1 levels than healthy controls (170.10 \u00b1 84.71 pg\/ml vs 97.41 \u00b1 40.64 pg\/ml; p &lt; 0.001). In patients with RA, plasma sTREM-1 levels were found to be correlated with DAS28, ESR, CRP, white blood cell counts, neutrophil counts, and plasma TNF-\u03b1 levels (r = 0.329, p = 0.005; r = 0.241, p = 0.043; r = 0.314, p &lt; 0.001; r = 0.261, p = 0.028; r = 0.278, p = 0.019; and r = 0.313, p = 0.009, respectively). Plasma sTREM-1 levels in patients with active disease status (DAS28 &gt; 3.2) were significantly higher than in those with low disease status (DAS28 \u2264 3.2; 208.89 \u00b1 100.14 pg\/ml vs 150.29 \u00b1 68.70 pg\/ml; p = 0.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Patients with RA had higher plasma sTREM-1 levels than healthy controls, and plasma sTREM-1 levels were correlated with disease activity measures, suggesting that plasma sTREM-1 could play a role in the inflammatory process associated with TNF-\u03b1, and that it may be a useful disease activity marker in RA.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.111218","type":"journal-article","created":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T21:38:57Z","timestamp":1331847537000},"page":"933-938","source":"Crossref","is-referenced-by-count":26,"title":["Levels of Plasma-soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) Are Correlated with Disease Activity in 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