{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T13:37:13Z","timestamp":1769261833974,"version":"3.49.0"},"reference-count":23,"publisher":"The Journal of Rheumatology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p>Psoriasis vulgaris (PsV) and psoriatic arthritis (PsA) are interrelated disorders, PsA representing a disease within a disease. From an epidemiological perspective, the genetic contributions of PsV and PsA are now well documented. <jats:italic>HLA-C<\/jats:italic> is firmly established as a PsV\/PsA gene, with <jats:italic>HLA-Cw*0602<\/jats:italic> as a major risk allele. Fine-mapping studies within the MHC region in PsV and PsA have identified novel loci that are independent of the <jats:italic>HLA-Cw6<\/jats:italic> allele. Recent genome-wide association scans have led to a substantial increase in the number of candidate genes reaching genome-wide significance in PsV and PsA cohorts. Most of these genes can be grouped into an integrated pathogenic model of PsV\/psoriatic disease comprising distinct signaling networks affecting skin barrier function (<jats:italic>LCE3<\/jats:italic>, <jats:italic>DEFB4<\/jats:italic>, <jats:italic>GJB2<\/jats:italic>), innate immune responses involving nuclear factor-\u03baB and interferon signaling (<jats:italic>TNFAIP3<\/jats:italic>, <jats:italic>TNIP1<\/jats:italic>, <jats:italic>NFKBIA<\/jats:italic>, <jats:italic>REL<\/jats:italic>, <jats:italic>FBXL19<\/jats:italic>, <jats:italic>TYK2<\/jats:italic>, <jats:italic>NOS2<\/jats:italic>), and adaptive immune responses involving CD8 T lymphocytes and interleukin 23 (IL-23)\/IL-17-mediated lymphocyte signaling (<jats:italic>HLA-C<\/jats:italic>, <jats:italic>IL12B<\/jats:italic>, <jats:italic>IL23R<\/jats:italic>, <jats:italic>IL23A<\/jats:italic>, <jats:italic>TRAF3IP2<\/jats:italic>, <jats:italic>ERAP1<\/jats:italic>). Further development of a global genetic risk score and inclusion of potential gene\/gene and gene\/environment interactions will likely enhance the predictive value of recently identified genetic variants.<\/jats:p>","DOI":"10.3899\/jrheum.111242","type":"journal-article","created":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T15:40:00Z","timestamp":1328110800000},"page":"431-433","source":"Crossref","is-referenced-by-count":29,"title":["Genetics of Psoriasis and Psoriatic Arthritis: A Report from the GRAPPA 2010 Annual Meeting: Figure 1."],"prefix":"10.3899","volume":"39","author":[{"given":"PROTON","family":"RAHMAN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAMES T.","family":"ELDER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2012,2,1]]},"reference":[{"key":"2018112909272973000_39.2.431.1","doi-asserted-by":"publisher","DOI":"10.1086\/503821"},{"key":"2018112909272973000_39.2.431.2","first-page":"1449","article-title":"Genetics of psoriasis and psoriatic arthritis: Update and future direction","volume":"35","author":"Duffin","year":"2008","journal-title":"J Rheumatol"},{"key":"2018112909272973000_39.2.431.3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000606"},{"key":"2018112909272973000_39.2.431.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2011.01670.x"},{"key":"2018112909272973000_39.2.431.5","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.133561"},{"key":"2018112909272973000_39.2.431.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(03)00125-6"},{"key":"2018112909272973000_39.2.431.7","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1001\/archderm.137.11.1447","article-title":"The genetics of psoriasis 2001: The odyssey continues","volume":"137","author":"Elder","year":"2001","journal-title":"Arch Dermatol"},{"key":"2018112909272973000_39.2.431.8","doi-asserted-by":"publisher","DOI":"10.1038\/ng.694"},{"key":"2018112909272973000_39.2.431.9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000041"},{"key":"2018112909272973000_39.2.431.10","doi-asserted-by":"publisher","DOI":"10.1038\/ng.311"},{"key":"2018112909272973000_39.2.431.11","doi-asserted-by":"publisher","DOI":"10.1038\/ng.689"},{"key":"2018112909272973000_39.2.431.12","doi-asserted-by":"publisher","DOI":"10.1038\/ng.688"},{"key":"2018112909272973000_39.2.431.13","doi-asserted-by":"publisher","DOI":"10.1038\/ng.313"},{"key":"2018112909272973000_39.2.431.14","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.48"},{"key":"2018112909272973000_39.2.431.15","doi-asserted-by":"publisher","DOI":"10.1038\/ng.690"},{"key":"2018112909272973000_39.2.431.16","doi-asserted-by":"publisher","DOI":"10.1038\/ni1439"},{"key":"2018112909272973000_39.2.431.17","doi-asserted-by":"publisher","DOI":"10.1038\/ni0307-232"},{"key":"2018112909272973000_39.2.431.18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019454"},{"key":"2018112909272973000_39.2.431.19","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380619"},{"key":"2018112909272973000_39.2.431.20","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.064972"},{"key":"2018112909272973000_39.2.431.21","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.143123"},{"key":"2018112909272973000_39.2.431.22","doi-asserted-by":"publisher","DOI":"10.1002\/art.23558"},{"key":"2018112909272973000_39.2.431.23","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3579(94)80024-3"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.111242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T18:08:54Z","timestamp":1543514934000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.111242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2,1]]},"published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.3899\/jrheum.111242"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.111242","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}