{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T17:45:06Z","timestamp":1759340706935},"reference-count":15,"publisher":"The Journal of Rheumatology","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>We evaluated whether a single-nucleotide polymorphism (SNP) of the<jats:italic>TRAF6<\/jats:italic>gene previously associated with systemic lupus erythematosus and rheumatoid arthritis may be a common risk factor for systemic sclerosis (SSc) and giant cell arteritis (GCA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>A total of 1185 patients with SSc, 479 patients with biopsy-proven GCA, and 1442 unrelated healthy controls of white Spanish origin were genotyped for the rs540386 variant using a specifically designed TaqMan<jats:sup>\u00a9<\/jats:sup>allele discrimination assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>No significant associations of this SNP with global SSc or GCA were found. This was also the case when the potential associations of the<jats:italic>TRAF6<\/jats:italic>polymorphism with the main clinical phenotypes of the 2 diseases (e.g., limited cutaneous and diffuse cutaneous SSc, or presence of polymyalgia rheumatica and visual ischemic manifestations in GCA) were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Our data do not support a role of the rs540386<jats:italic>TRAF6<\/jats:italic>variant as a key component of the genetic network underlying SSc and GCA.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.120038","type":"journal-article","created":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T00:34:02Z","timestamp":1337128442000},"page":"1275-1279","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of a Shared Autoimmune Disease-associated Polymorphism of TRAF6 in Systemic Sclerosis and Giant Cell Arteritis"],"prefix":"10.3899","volume":"39","author":[{"given":"F. DAVID","family":"CARMONA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AURORA","family":"SERRANO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LUIS","family":"RODR\u00cdGUEZ-RODR\u00cdGUEZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOS\u00c9 LUIS","family":"CALLEJAS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CARMEN P.","family":"SIME\u00d3N","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PATRICIA","family":"CARREIRA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SANTOS","family":"CASTA\u00d1EDA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROSER","family":"SOLANS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICARDO","family":"BLANCO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Spanish Scleroderma Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Spanish Giant Cell Arteritis Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MIGUEL A.","family":"GONZ\u00c1LEZ-GAY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAVIER","family":"MART\u00cdN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2012,5,15]]},"reference":[{"key":"2018112909275542000_39.6.1275.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1100030"},{"key":"2018112909275542000_39.6.1275.2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2489"},{"key":"2018112909275542000_39.6.1275.3","doi-asserted-by":"publisher","DOI":"10.1038\/ng.479"},{"key":"2018112909275542000_39.6.1275.4","doi-asserted-by":"crossref","unstructured":"Namjou B Choi CB Harley ITW Alarc\u00f3n-Riquelme ME Kelly JA Glenn SB Evaluation of TRAF6 in a large multi-ancestral lupus cohort. Arthritis Rheum 2012 Jan 9 [E-pub ahead of print].","DOI":"10.1002\/art.34361"},{"key":"2018112909275542000_39.6.1275.5","doi-asserted-by":"crossref","unstructured":"Ha H Han D Choi Y . TRAF-mediated TNFR-family signaling. Curr Protoc Immunol 2009;Chapter 11:Unit 11.9D.","DOI":"10.1002\/0471142735.im1109ds87"},{"key":"2018112909275542000_39.6.1275.6","doi-asserted-by":"crossref","unstructured":"Martin JE Bossini-Castillo L Martin J . Unraveling the genetic component of systemic sclerosis. Hum Genet 2012 Jan 5 [E-pub ahead of print].","DOI":"10.1007\/s00439-011-1137-z"},{"key":"2018112909275542000_39.6.1275.7","doi-asserted-by":"publisher","DOI":"10.1002\/art.24459"},{"key":"2018112909275542000_39.6.1275.8","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"2018112909275542000_39.6.1275.9","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330810"},{"key":"2018112909275542000_39.6.1275.10","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110685"},{"key":"2018112909275542000_39.6.1275.11","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200275"},{"key":"2018112909275542000_39.6.1275.12","first-page":"202","article-title":"Scleroderma (systemic sclerosis): Classification, subsets and pathogenesis","volume":"15","author":"LeRoy","year":"1988","journal-title":"J Rheumatol"},{"key":"2018112909275542000_39.6.1275.13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2443.2011.01500.x"},{"key":"2018112909275542000_39.6.1275.14","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-70630-6_10"},{"key":"2018112909275542000_39.6.1275.15","doi-asserted-by":"publisher","DOI":"10.1038\/ng.565"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.120038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T15:49:52Z","timestamp":1561736992000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.120038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,15]]},"references-count":15,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,6,1]]},"published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.3899\/jrheum.120038"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.120038","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"type":"print","value":"0315-162X"},{"type":"electronic","value":"1499-2752"}],"subject":[],"published":{"date-parts":[[2012,5,15]]}}}