{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:05:30Z","timestamp":1770336330018,"version":"3.49.0"},"reference-count":13,"publisher":"The Journal of Rheumatology","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>T helper cells lacking CD28 (CD4+CD28\u2013) have been implicated in the pathogenesis of granulomatosis with polyangiitis (Wegener; GPA) and microscopic polyangiitis (MPA). Expansions of CD4+CD28\u2013 and CD8+CD28\u2013 T cells have also been associated with latent cytomegalovirus (CMV) infection. We assessed these T cells with and without coexpression of CD56 and CD57 in relation to vasculitis as well as CMV status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Blood from 16 patients in remission (12 GPA, 4 MPA), 18 patients with active vasculitis (12 GPA, 6 MPA), and 20 healthy controls was examined by flow cytometry for expression of CD4, CD8, CD56, CD57, and CD28 on T cells. The influence of age, CMV status, presence of disease, and disease activity on T cell subpopulations was tested with multiple regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>In active vasculitis, the total numbers and proportion of lymphocytes were decreased. Total numbers of CD4+, CD8+, CD4+CD28\u2013, CD8+CD28\u2013, CD4+CD57+, and CD8+CD57+ T subpopulations were decreased to the same extent, implying unchanged proportions. Multivariate analyses showed no associations between vasculitis and CD28\u2013 or CD57+ T subpopulations, whereas immunoglobulin G antibodies to CMV were associated with expanded proportions of CD28\u2013 and CD57+ T cells, in both the CD4+ and the CD8+ compartments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>CD28\u2013 and CD57+ T cells were associated with latent CMV infection and not with a diagnosis of GPA or MPA. Vasculitis assessment should include CMV status.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.120060","type":"journal-article","created":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T00:12:47Z","timestamp":1341187967000},"page":"1840-1843","source":"Crossref","is-referenced-by-count":24,"title":["Expansions of CD4+CD28\u2013 and CD8+CD28\u2013 T cells in Granulomatosis with Polyangiitis and Microscopic Polyangiitis Are Associated with Cytomegalovirus Infection But Not with Disease Activity"],"prefix":"10.3899","volume":"39","author":[{"given":"PER","family":"ERIKSSON","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRISTINA","family":"SANDELL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KARIN","family":"BACKTEMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAN","family":"ERNERUDH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2012,7,1]]},"reference":[{"key":"2018112909283429000_39.9.1840.1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24576"},{"key":"2018112909283429000_39.9.1840.2","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.2741\/3487","article-title":"Dysregulation of CD8+ lymphocyte apoptosis, chronic disease, and immune regulation","volume":"14","author":"Wood","year":"2009","journal-title":"Front Biosci"},{"key":"2018112909283429000_39.9.1840.3","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0809566"},{"key":"2018112909283429000_39.9.1840.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(01)00212-1"},{"key":"2018112909283429000_39.9.1840.5","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.4.1984"},{"key":"2018112909283429000_39.9.1840.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2005.03.006"},{"key":"2018112909283429000_39.9.1840.7","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-010-1023-3"},{"key":"2018112909283429000_39.9.1840.8","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/intimm\/dxr035","article-title":"The \u201cT-cell-ness\u201d of NK cells: Unexpected similarities between NK cells and T cells","volume":"23","author":"Narni-Mancinelli","year":"2011","journal-title":"Int Immunol"},{"key":"2018112909283429000_39.9.1840.9","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1365-2249.1994.tb07020.x","article-title":"CD8 lymphocytosis in primary cytomegalovirus (CMV) infection of allograft recipients: Expansion of an uncommon CD8+57-subset and its progressive replacement by CD8+CD57+ T cells","volume":"95","author":"Labalette","year":"1994","journal-title":"Clin Exp Immunol"},{"key":"2018112909283429000_39.9.1840.10","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370206"},{"key":"2018112909283429000_39.9.1840.11","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100074"},{"key":"2018112909283429000_39.9.1840.12","doi-asserted-by":"publisher","DOI":"10.1002\/art.30366"},{"key":"2018112909283429000_39.9.1840.13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02471.x"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.120060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T18:19:06Z","timestamp":1543515546000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.120060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,1]]},"references-count":13,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2012,9,1]]},"published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.3899\/jrheum.120060"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.120060","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,1]]}}}