{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:23:15Z","timestamp":1787030595515,"version":"build-2736575974"},"reference-count":36,"publisher":"The Journal of Rheumatology","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective.<\/jats:title>\n                    <jats:p>To define the minimally important change (MIC) in the SpondyloArthritis Research Consortium of Canada (SPARCC) spine and sacroiliac (SI) joint magnetic resonance imaging (MRI) indices in patients with ankylosing spondylitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>\n                      MRI scans were performed during a placebo-controlled trial of adalimumab (no.\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT00195819\">NCT00195819<\/jats:ext-link>\n                      ). Two independent readers, blinded to treatment and sequence, determined SPARCC scores for the spine and SI joints and a global evaluation of change (GEC; \u201cmuch worse,\u201d \u201cworse,\u201d \u201cno change,\u201d \u201cbetter,\u201d or \u201cmuch better\u201d; categories other than \u201cno change\u201d were pooled together as \u201cchange\u201d) between baseline\u2013Week 12, baseline\u2013Week 52, and Weeks 12\u201352. Mean absolute changes in SPARCC scores (95% CI) were calculated for each interval, treatment group, and GEC. Receiver-operating characteristic (ROC) curves were used to identify the MIC. Relationships of MIC to clinical responses were examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>Reader agreement on GEC evaluations was &gt; 70%. Changes in SPARCC scores were generally comparable between time intervals and treatment groups for \u201cchange\u201d and \u201cno change\u201d categories and were combined for each category; change in score was significantly associated with GEC of \u201cchange\u201d (area under ROC curves: spine 0.839; SI joints 0.960). ROC curves peaked at values of 5.0 for the spine and 2.5 for SI joints. Placebo-treated patients achieving &gt; 2.5 unit improvement in SI joint score had significantly better clinical responses than placebo-treated patients who did not achieve such improvement. MRI and clinical responses were uncoupled in adalimumab-treated patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>We propose that changes of 5.0 for the spine and 2.5 for SI joints define the MIC for the SPARCC MRI indices.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3899\/jrheum.120131","type":"journal-article","created":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T20:12:47Z","timestamp":1341173567000},"page":"1666-1674","source":"Crossref","is-referenced-by-count":35,"title":["Defining the Minimally Important Change for the SpondyloArthritis Research Consortium of Canada Spine and Sacroiliac Joint Magnetic Resonance Imaging Indices for Ankylosing Spondylitis"],"prefix":"10.3899","volume":"39","author":[{"given":"WALTER P.","family":"MAKSYMOWYCH","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROBERT G.","family":"LAMBERT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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