{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:04:20Z","timestamp":1791180260731,"version":"4.1.0"},"reference-count":37,"publisher":"The Journal of Rheumatology","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2012,11]]},"abstract":"\n Objective.<\/jats:title>\n \n Immune complexes play an important role in the pathogenesis of primary Sj\u00f6gren\u2019s syndrome (pSS). Crosslinking of the neutrophil-specific Fc-\u03b3 receptor 3b (FCGR3B) facilitates immune complex clearance, and copy number variation (CNV) of the\n FCGR3B<\/jats:italic>\n gene is known to reduce the uptake, and potentially clearance, of circulating immune complexes. Our objective was to determine whether\n FCGR3B<\/jats:italic>\n CNV is a risk factor for pSS.\n <\/jats:p>\n <\/jats:sec>\n \n Methods.<\/jats:title>\n \n This was a cross-sectional study of patients with established pSS (n = 174) and population-matched controls (n = 162).\n FCGR3B<\/jats:italic>\n CNV was determined by a quantitative real-time polymerase chain reaction assay, using genomic DNA as template and Taqman chemistry. Reactions were performed as a duplex, with RNAse P as the reference gene. Clinical and serological data were analyzed for their association with\n FCGR3B<\/jats:italic>\n copy number (CN).\n <\/jats:p>\n <\/jats:sec>\n \n Results.<\/jats:title>\n \n Low\n FCGR3B<\/jats:italic>\n CN (< 2 copies) was a risk factor for pSS in this cohort (p = 0.016), and combined results from this and a previous study yielded an overall OR of 2.3 (95% CI 1.3, 3.9, p = 0.003). Among patients with pSS in our cohort, low\n FCGR3B<\/jats:italic>\n CN was not associated with anti-Ro \u00b1 La autoantibodies, but was associated with lower rheumatoid factor titers (p = 0.001) and serum IgG levels (p = 0.031).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion.<\/jats:title>\n \n We confirmed that, similarly to other systemic autoimmune diseases,\n FCGR3B<\/jats:italic>\n CN is a genetic susceptibility factor for pSS. As in rheumatoid arthritis, the mechanism does not appear to be related to seropositivity for characteristic autoantibodies.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3899\/jrheum.120294","type":"journal-article","created":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T20:47:29Z","timestamp":1346532449000},"page":"2142-2147","source":"Crossref","is-referenced-by-count":35,"title":["Low Copy Number of the Fc-\u03b3 Receptor 3B Gene\n FCGR3B<\/i>\n Is a Risk Factor for Primary Sj\u00f6gren\u2019s Syndrome"],"prefix":"10.3899","volume":"39","author":[{"given":"JOHANNES C.","family":"NOSSENT","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MAUREEN","family":"RISCHMUELLER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SUE","family":"LESTER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2012,9,1]]},"reference":[{"key":"2018112909282833000_39.11.2142.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.11.004"},{"key":"2018112909282833000_39.11.2142.2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.025676"},{"key":"2018112909282833000_39.11.2142.3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.autrev.2010.09.001","article-title":"The meaning of anti-Ro and anti-La antibodies in primary Sjogren\u2019s syndrome","volume":"10","author":"Hernandez-Molina","year":"2010","journal-title":"Autoimmun Rev"},{"key":"2018112909282833000_39.11.2142.4","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.semarthrit.2010.07.006","article-title":"Relation of systemic autoantibodies to the number of extraglandular manifestations in primary Sjogren\u2019s Syndrome: A retrospective analysis of 65 patients in the Netherlands","volume":"40","author":"ter Borg","year":"2010","journal-title":"Semin Arthritis Rheum"},{"key":"2018112909282833000_39.11.2142.5","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1996.0084"},{"key":"2018112909282833000_39.11.2142.6","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0607421"},{"key":"2018112909282833000_39.11.2142.7","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0173"},{"key":"2018112909282833000_39.11.2142.8","doi-asserted-by":"publisher","DOI":"10.1002\/art.22004"},{"key":"2018112909282833000_39.11.2142.9","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken246"},{"key":"2018112909282833000_39.11.2142.10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1998.00504.x"},{"key":"2018112909282833000_39.11.2142.11","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-100708-204735"},{"key":"2018112909282833000_39.11.2142.12","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20997"},{"key":"2018112909282833000_39.11.2142.13","doi-asserted-by":"publisher","DOI":"10.1038\/nri2206"},{"key":"2018112909282833000_39.11.2142.14","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.771170"},{"key":"2018112909282833000_39.11.2142.15","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2009.35"},{"key":"2018112909282833000_39.11.2142.16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05132.x"},{"key":"2018112909282833000_39.11.2142.17","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20072413"},{"key":"2018112909282833000_39.11.2142.18","doi-asserted-by":"publisher","DOI":"10.1038\/ng2046"},{"key":"2018112909282833000_39.11.2142.19","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2009.71"},{"key":"2018112909282833000_39.11.2142.20","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq216"},{"key":"2018112909282833000_39.11.2142.21","doi-asserted-by":"publisher","DOI":"10.1186\/ar3731"},{"key":"2018112909282833000_39.11.2142.22","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22031"},{"key":"2018112909282833000_39.11.2142.23","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.554"},{"key":"2018112909282833000_39.11.2142.24","first-page":"2406","article-title":"Increased severity of lower urinary tract symptoms and daytime somnolence in primary Sjogren\u2019s syndrome","volume":"30","author":"Walker","year":"2003","journal-title":"J Rheumatol"},{"key":"2018112909282833000_39.11.2142.25","unstructured":"R Development Core Team . 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