{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T01:01:58Z","timestamp":1784336518294,"version":"3.55.0"},"reference-count":12,"publisher":"The Journal of Rheumatology","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Rituximab (RTX) therapy is a treatment option in patients with refractory antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We investigated the tolerability and clinical efficacy of RTX in a cohort of patients with refractory AAV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Clinical and safety data of patients with AAV treated with RTX were retrospectively assessed from the data of a German national registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>In total, 58 patients were included in this analysis (50\/58 with granulomatosis with polyangiitis; 8\/58 with microscopic polyangiitis who received at least 1 cycle, 17 patients who received 2 cycles, and 3 patients who received 3 cycles of RTX). Response was classified as complete and partial in 22 (40%) and in 29 cases (52.7%), respectively. Four patients (7.3%) were classified as nonresponders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>RTX was well tolerated with good clinical efficacy in patients with refractory AAV.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.120482","type":"journal-article","created":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T20:40:33Z","timestamp":1347741633000},"page":"2153-2156","source":"Crossref","is-referenced-by-count":30,"title":["Efficacy and Safety of Rituximab Treatment in Patients with Antineutrophil Cytoplasmic Antibody-associated Vasculitides: Results from a German Registry 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