{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T23:18:57Z","timestamp":1781911137512,"version":"3.54.5"},"reference-count":37,"publisher":"The Journal of Rheumatology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To compare 3 different cholecalciferol supplementation regimens in patients with rheumatic diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>One hundred fifty-four patients who completed a 6-month course of cholecalciferol supplementation, of whom 111 had an autoimmune\/inflammatory rheumatic disease (ARD) and 43 osteoarthritis (NARD), were retrospectively identified from a database of 872 consecutive adult patients who attended a tertiary level immuno-rheumatology clinic from 2007 to 2010. Patients with renal failure or primary hyperparathyroidism were excluded. Plasma 25-hydroxy vitamin D [25(OH)D] and parathyroid hormone (PTH) concentrations were evaluated at baseline and after completion of treatment with (i) a single oral dose of cholecalciferol 300,000 IU, followed by oral cholecalciferol 800\u20131000 IU daily for 6 months [high-dose loading treatment (HLT) group; n = 40]; (ii) a single oral dose of cholecalciferol 100,000 IU, followed by daily oral cholecalciferol as above [low-dose loading treatment (LLT) group; n = 30]; or (iii) daily oral cholecalciferol as above but without the loading dose [standard therapy (ST); n = 84].<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>The rates of serum 25(OH)D and PTH normalization (defined as values &gt; 75 nmol\/l and &lt; 72.9 pg\/ml, respectively) were as follows: HLT, 52.5% (95% CI 37.5\u201368.5) and 69.2% (95% CI 54.7\u201383.3); LLT, 36.7% (95% CI 19.7\u201354.3) and 53.8% (95% CI 36.2\u201371.8); ST, 31.0% (95% CI 21.1\u201340.9) and 35.0% (95% CI 14.1\u201355.9). All regimes increased 25(OH)D (p &lt; 0.001) but only HLT reduced PTH (p &lt; 0.01) in comparison to baseline. The ARD group had a similar 25(OH)D increase but a smaller PTH reduction than the NARD (p &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>An HLT cholecalciferol regimen is needed to correct hypovitaminosis D of patients with rheumatic diseases, with superior 25(OH)D normalization and PTH suppression rates at 6 months.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.120536","type":"journal-article","created":{"date-parts":[[2012,12,15]],"date-time":"2012-12-15T21:54:48Z","timestamp":1355608488000},"page":"166-172","source":"Crossref","is-referenced-by-count":35,"title":["Superiority of a High Loading Dose of Cholecalciferol to Correct Hypovitaminosis D in Patients with Inflammatory\/Autoimmune Rheumatic Diseases"],"prefix":"10.3899","volume":"40","author":[{"given":"PIER PAOLO","family":"SAINAGHI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MATTIA","family":"BELLAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALESSANDRA","family":"NERVIANI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DANIELE","family":"SOLA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROSSELLA","family":"MOLINARI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHIARA","family":"CERUTTI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIO","family":"PIRISI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2012,12,15]]},"reference":[{"key":"2018112909311446000_40.2.166.1","doi-asserted-by":"publisher","DOI":"10.4065\/81.3.353"},{"key":"2018112909311446000_40.2.166.2","doi-asserted-by":"publisher","DOI":"10.1210\/er.22.4.477"},{"key":"2018112909311446000_40.2.166.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-005-1867-7"},{"key":"2018112909311446000_40.2.166.4","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050030"},{"key":"2018112909311446000_40.2.166.5","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken203"},{"key":"2018112909311446000_40.2.166.6","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1590\/S1807-59322010001100024","article-title":"Glucocorticoid-induced osteoporosis in rheumatic diseases","volume":"65","author":"Pereira","year":"2010","journal-title":"Clinics (Sao Paulo)"},{"key":"2018112909311446000_40.2.166.7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.8.2729"},{"key":"2018112909311446000_40.2.166.8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.16.1999"},{"key":"2018112909311446000_40.2.166.9","unstructured":"Institute of Medicine . 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