{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:39:57Z","timestamp":1778837997888,"version":"3.51.4"},"reference-count":61,"publisher":"The Journal of Rheumatology","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To investigate the expression of peroxisome proliferator-activated receptors (PPAR) \u03b1, \u03b2, and \u03b3, and hematopoietic and lipocalin-type prostaglandin D synthase (H- and L-PGDS) over the course of osteoarthritis (OA) in the spontaneous Hartley guinea pig and the anterior cruciate ligament transection dog models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Guinea pigs were sacrificed at 2 (control group), 4, 8, and 12 months of age (n = 5 per group). Non-operated (control) and operated dogs were sacrificed at 4, 8, and 12 weeks postsurgery. Cartilage was evaluated histologically using the Osteoarthritis Research Society International (OARSI) guidelines. The expression of PPAR-\u03b1, \u03b2, \u03b3, and H- and L-PGDS was evaluated by real-time PCR and immunohistochemistry. The nonparametric Spearman test was used for correlation analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>PPAR-\u03b1, \u03b2, and \u03b3 were detected in medial tibial plateau from control animals in both the spontaneous and surgical models. Levels of PPAR-\u03b1 and \u03b2 did not change over the course of OA, whereas PPAR-\u03b3 levels decreased during progression of disease. We also observed that the expression of H-PGDS remained unchanged, whereas L-PGDS increased over the course of OA. PPAR-\u03b3 levels correlated negatively, whereas L-PGDS levels correlated positively, with the histological score of OA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>The level of PPAR-\u03b3 decreased, whereas level of L-PGDS increased during the progression of OA. These data suggest that reduced expression of PPAR-\u03b3 may contribute to the pathogenesis of OA, whereas enhanced expression of L-PGDS may be part of a reparative process.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.120738","type":"journal-article","created":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T00:59:34Z","timestamp":1364864374000},"page":"877-890","source":"Crossref","is-referenced-by-count":19,"title":["Expression of Peroxisome Proliferator-activated Receptors \u03b1, \u03b2, \u03b3, and H- and L-Prostaglandin D Synthase During Osteoarthritis in the Spontaneous Hartley Guinea Pig and Experimental Dog Models"],"prefix":"10.3899","volume":"40","author":[{"given":"Sarah-Salwa","family":"Nebbaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima Ezzahra","family":"El Mansouri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Afif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohit","family":"Kapoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Benderdour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Pelletier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanne","family":"Martel-Pelletier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Fahmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2013,4,1]]},"reference":[{"key":"2018112909313801000_40.6.877.1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.196"},{"key":"2018112909313801000_40.6.877.2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2592"},{"key":"2018112909313801000_40.6.877.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.08.027"},{"key":"2018112909313801000_40.6.877.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2008.10.001"},{"key":"2018112909313801000_40.6.877.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.03.008"},{"key":"2018112909313801000_40.6.877.6","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.bbalip.2007.02.004","article-title":"Peroxisome proliferator-activated receptors (PPARs) in skin health, repair and disease","volume":"1771","author":"Michalik","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"2018112909313801000_40.6.877.7","doi-asserted-by":"crossref","first-page":"780452","DOI":"10.1155\/2008\/780452","article-title":"Peroxisome proliferator-activated receptor beta\/delta in the brain: Facts and hypothesis","volume":"2008","author":"Hall","year":"2008","journal-title":"PPAR Res"},{"key":"2018112909313801000_40.6.877.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2008.07.015"},{"key":"2018112909313801000_40.6.877.9","doi-asserted-by":"crossref","first-page":"679137","DOI":"10.1155\/2008\/679137","article-title":"Peroxisome proliferators-activated receptor (PPAR) modulators and metabolic disorders","volume":"2008","author":"Cho","year":"2008","journal-title":"PPAR Res"},{"key":"2018112909313801000_40.6.877.10","doi-asserted-by":"publisher","DOI":"10.1007\/s10165-010-0347-x"},{"key":"2018112909313801000_40.6.877.11","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90194-9"},{"key":"2018112909313801000_40.6.877.12","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90193-0"},{"key":"2018112909313801000_40.6.877.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-6980(02)00042-4"},{"key":"2018112909313801000_40.6.877.14","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200103)44:3<595::AID-ANR108>3.0.CO;2-8"},{"key":"2018112909313801000_40.6.877.15","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2002.0835"},{"key":"2018112909313801000_40.6.877.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02614-X"},{"key":"2018112909313801000_40.6.877.17","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.16.12243"},{"key":"2018112909313801000_40.6.877.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.06.090"},{"key":"2018112909313801000_40.6.877.19","first-page":"887","article-title":"Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes","volume":"32","author":"Li","year":"2005","journal-title":"J Rheumatol"},{"key":"2018112909313801000_40.6.877.20","first-page":"561","article-title":"Effect of peroxisome proliferator activated receptor (PPAR) gamma agonists on prostaglandins cascade in joint cells","volume":"43","author":"Moulin","year":"2006","journal-title":"Biorheology"},{"key":"2018112909313801000_40.6.877.21","doi-asserted-by":"publisher","DOI":"10.1186\/ar1830"},{"key":"2018112909313801000_40.6.877.22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312708200"},{"key":"2018112909313801000_40.6.877.23","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2002.0827"},{"key":"2018112909313801000_40.6.877.24","doi-asserted-by":"publisher","DOI":"10.1124\/mol.65.2.309"},{"key":"2018112909313801000_40.6.877.25","doi-asserted-by":"publisher","DOI":"10.1186\/ar2652"},{"key":"2018112909313801000_40.6.877.26","doi-asserted-by":"publisher","DOI":"10.1002\/art.22726"},{"key":"2018112909313801000_40.6.877.27","doi-asserted-by":"publisher","DOI":"10.1002\/art.20792"},{"key":"2018112909313801000_40.6.877.28","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199807)41:7<1275::AID-ART19>3.0.CO;2-T"},{"issue":"Suppl 3","key":"2018112909313801000_40.6.877.29","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/j.joca.2010.04.015","article-title":"The OARSI histopathology initiative \u2014 Recommendations for histological assessments of osteoarthritis in the guinea pig","volume":"18","author":"Kraus","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"issue":"Suppl 3","key":"2018112909313801000_40.6.877.30","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1016\/j.joca.2010.04.017","article-title":"The OARSI histopathology initiative \u2014 Recommendations for histological assessments of osteoarthritis in the dog","volume":"18","author":"Cook","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"2018112909313801000_40.6.877.31","doi-asserted-by":"publisher","DOI":"10.1186\/ar2151"},{"key":"2018112909313801000_40.6.877.32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07570.x"},{"key":"2018112909313801000_40.6.877.33","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310416"},{"key":"2018112909313801000_40.6.877.34","first-page":"115","article-title":"Osteoarthrosis in guinea pigs: Histopathologic and scanning electron microscopic features","volume":"39","author":"Bendele","year":"1989","journal-title":"Lab Anim Sci"},{"key":"2018112909313801000_40.6.877.35","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(96)80016-1"},{"key":"2018112909313801000_40.6.877.36","first-page":"363","article-title":"Animal models of osteoarthritis","volume":"1","author":"Bendele","year":"2001","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"2018112909313801000_40.6.877.37","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(96)80003-3"},{"key":"2018112909313801000_40.6.877.38","doi-asserted-by":"publisher","DOI":"10.1002\/art.20149"},{"key":"2018112909313801000_40.6.877.39","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2009.02.015"},{"key":"2018112909313801000_40.6.877.40","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/art.1780260708","article-title":"Collagenolytic activity and collagen matrix breakdown of the articular cartilage in the Pond-Nuki dog model of osteoarthritis","volume":"26","author":"Pelletier","year":"1983","journal-title":"Arthritis Rheum"},{"key":"2018112909313801000_40.6.877.41","first-page":"1585","article-title":"Collagenase-1 and collagenase-3 synthesis in normal and early experimental osteoarthritic canine cartilage: An immunohistochemical study","volume":"25","author":"Fernandes","year":"1998","journal-title":"J Rheumatol"},{"key":"2018112909313801000_40.6.877.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2003.11.008"},{"key":"2018112909313801000_40.6.877.43","doi-asserted-by":"publisher","DOI":"10.1002\/art.22836"},{"key":"2018112909313801000_40.6.877.44","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M809042200"},{"key":"2018112909313801000_40.6.877.45","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-1704"},{"key":"2018112909313801000_40.6.877.46","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000073585.50092.14"},{"key":"2018112909313801000_40.6.877.47","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00131-4"},{"key":"2018112909313801000_40.6.877.48","doi-asserted-by":"publisher","DOI":"10.1002\/art.23136"},{"key":"2018112909313801000_40.6.877.49","doi-asserted-by":"publisher","DOI":"10.1002\/art.21728"},{"key":"2018112909313801000_40.6.877.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.10.009"},{"key":"2018112909313801000_40.6.877.51","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21516"},{"key":"2018112909313801000_40.6.877.52","doi-asserted-by":"crossref","first-page":"R146","DOI":"10.1186\/ar2581","article-title":"Increased expression of lipocalin-type prostaglandin D2 synthase in osteoarthritic cartilage","volume":"10","author":"Zayed","year":"2008","journal-title":"Arthritis Res Ther"},{"key":"2018112909313801000_40.6.877.53","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1002\/jor.21093","article-title":"Comparison of differential biomarkers of osteoarthritis with and without posttraumatic injury in the Hartley guinea pig model","volume":"28","author":"Wei","year":"2010","journal-title":"J Orthop Res"},{"key":"2018112909313801000_40.6.877.54","first-page":"279","article-title":"Experimental osteoarthritis in guinea-pigs","volume":"71","author":"Meacock","year":"1990","journal-title":"J Exp Pathol"},{"key":"2018112909313801000_40.6.877.55","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.05.001"},{"key":"2018112909313801000_40.6.877.56","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(96)80004-5"},{"key":"2018112909313801000_40.6.877.57","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.041211"},{"key":"2018112909313801000_40.6.877.58","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.05.017"},{"key":"2018112909313801000_40.6.877.59","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61209"},{"key":"2018112909313801000_40.6.877.60","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200113202"},{"key":"2018112909313801000_40.6.877.61","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-184861"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.120738","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T17:35:13Z","timestamp":1595612113000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.120738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,1]]},"references-count":61,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,6,1]]},"published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.3899\/jrheum.120738"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.120738","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,1]]}}}