{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:07:10Z","timestamp":1760267230571},"reference-count":40,"publisher":"The Journal of Rheumatology","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Insights into the pathogenesis of inflammatory myopathies have led to new diagnostic methods. The aims of our study were (1) to evaluate the consequences of using the classification of Amato\/European Neuromuscular Centre Workshop (ENMC) compared to that of Bohan and Peter; and (2) to evaluate any diagnostic benefit in using an extended pathological investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>From a consecutive retrospective database, we evaluated 99 patients for classification. Patients with inclusion body myositis (IBM) were classified according to Griggs,<jats:italic>et al<\/jats:italic>. In addition to routine stainings and immunohistochemistry, a multilevel serial sectioning procedure was performed on paraffin-embedded material, to identify scarce pathological findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Classification according to Bohan and Peter could be performed for 83 of the 99 patients, whereas only 60 patients met the Amato\/ENMC criteria, the latter resulting in the following diagnostic groups: IBM (n = 18), nonspecific myositis (n = 14), polymyositis (n = 12), dermatomyositis (n = 10), dermatomyositis sine dermatitis (n = 5), and immune-mediated necrotizing myopathy (n = 1). Most of the Amato\/ENMC diagnostic groups harbored patients from several of the Bohan and Peter groups, which included a substantial group lacking proximal muscle weakness. The serial sectioning procedure was essential for classification of 9 patients (15%), and led to a more specific diagnosis for 13 patients (22%) according to Amato\/ENMC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>The classification of Amato\/ENMC was more restrictive, forming groups based on clinical criteria and specified myopathological findings, which clearly differed from the groups of the Bohan and Peter classification. An extended pathological investigation increased the diagnostic yield of a muscle biopsy and highlights the quantity and specificity of certain pathological findings.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.120804","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T08:27:39Z","timestamp":1367483259000},"page":"1173-1182","source":"Crossref","is-referenced-by-count":12,"title":["Classification and Diagnostic Investigation in Inflammatory Myopathies: A Study of 99 Patients"],"prefix":"10.3899","volume":"40","author":[{"given":"Olof","family":"Danielsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Lindvall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istvan","family":"Gati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Ernerudh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2013,5,1]]},"reference":[{"key":"2018112909314456000_40.7.1173.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"2018112909314456000_40.7.1173.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502202920807"},{"key":"2018112909314456000_40.7.1173.3","first-page":"649","article-title":"Myxovirus-like structures and accompanying nuclear changes in chronic polymyositis","volume":"86","author":"Chou","year":"1968","journal-title":"Arch Pathol"},{"key":"2018112909314456000_40.7.1173.4","first-page":"557","article-title":"Inclusion body myositis","volume":"2","author":"Chou","year":"1993","journal-title":"Baillieres Clin Neurol"},{"key":"2018112909314456000_40.7.1173.5","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1212\/WNL.20.3.205","article-title":"Picornavirus-like crystals in subacute polymyositis","volume":"20","author":"Chou","year":"1970","journal-title":"Neurology"},{"key":"2018112909314456000_40.7.1173.6","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1971.00480350043004"},{"key":"2018112909314456000_40.7.1173.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2004.02.006"},{"key":"2018112909314456000_40.7.1173.8","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380504"},{"key":"2018112909314456000_40.7.1173.9","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160206"},{"key":"2018112909314456000_40.7.1173.10","doi-asserted-by":"crossref","unstructured":"Arahata K Engel AG . 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