{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:26:58Z","timestamp":1761895618838,"version":"3.37.0"},"reference-count":42,"publisher":"The Journal of Rheumatology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"accepted":{"date-parts":[[2012,11,27]]},"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Clinical joint examination (CJE) is less time-consuming than ultrasound (US) in rheumatoid arthritis (RA). Low concordance between CJE and US would indicate that the 2 tests provide different types of information. Knowledge of factors associated with CJE\/US concordance would help to select patients and joints for US. Our objective was to identify factors associated with CJE\/US concordance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Seventy-six patients with RA requiring tumor necrosis factor-\u03b1 (TNF-\u03b1) antagonist therapy were included in a prospective, multicenter cohort. In each patient, 38 joints were evaluated. Synovitis was scored using CJE, B-mode US (B-US), and power Doppler US (PDUS). Joints whose kappa coefficient (\u03ba) for agreement CJE\/US was &lt; 0.1 were considered discordant. Multivariate analysis was performed to identify factors independently associated with CJE\/US concordance, defined as factors yielding p &lt; 0.05 and OR &gt; 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Concordance before TNF-\u03b1 antagonist therapy varied across joints for CJE\/US (\u03ba = \u22120.08 to 0.51) and B-US\/PDUS (\u03ba = 0.30 to 0.67). CJE\/US concordance was low at the metatarsophalangeal joints and shoulders (\u03ba &lt; 0.1). Before TNF-\u03b1 antagonist therapy, a low 28-joint Disease Activity Score (DAS28) was associated with good CJE\/B-US concordance, and no factors were associated with CJE\/PDUS concordance. After TNF-\u03b1 antagonist therapy, only the joint site was associated with CJE\/B-US concordance; joint site and short disease duration were associated with CJE\/PDUS concordance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Concordance between CJE and US is poor overall. US adds information to CJE, most notably at the metatarsophalangeal joints and shoulders. Usefulness is decreased for B-US when DAS28 is low and for PDUS when disease duration is short.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.120843","type":"journal-article","created":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T04:25:40Z","timestamp":1358310340000},"page":"244-252","source":"Crossref","is-referenced-by-count":23,"title":["Factors Influencing Concordance Between Clinical and Ultrasound Findings in Rheumatoid Arthritis"],"prefix":"10.3899","volume":"40","author":[{"given":"MARION","family":"Le BOEDEC","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SANDRINE","family":"JOUSSE-JOULIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEAN-FRAN\u00c7OIS","family":"FERLET","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"THIERRY","family":"MARHADOUR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00c9RARD","family":"CHALES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LAURENT","family":"GRANGE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00c9CILE","family":"HACQUARD-BOUDER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAMIEN","family":"LOEUILLE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00c9R\u00c9MIE","family":"SELLAM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEAN-DAVID","family":"ALBERT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JACQUES","family":"BENTIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ISABELLE","family":"CHARY-VALCKENAERE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIA-ANTONIETTA","family":"D\u2019AGOSTINO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FABIEN","family":"ETCHEPARE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PHILIPPE","family":"GAUDIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRISTOPHE","family":"HUDRY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MAXIME","family":"DOUGADOS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALAIN","family":"SARAUX","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2013,1,15]]},"reference":[{"key":"2025021211251274000_40.3.244.1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.007062"},{"key":"2025021211251274000_40.3.244.2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem286"},{"key":"2025021211251274000_40.3.244.3","doi-asserted-by":"publisher","DOI":"10.1002\/art.23945"},{"key":"2025021211251274000_40.3.244.4","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep171"},{"key":"2025021211251274000_40.3.244.5","doi-asserted-by":"publisher","DOI":"10.1002\/art.24596"},{"key":"2025021211251274000_40.3.244.6","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199911)42:11<2303::AID-ANR7>3.0.CO;2-4"},{"key":"2025021211251274000_40.3.244.7","first-page":"966","article-title":"Ultrasonography is superior to clinical examination in the detection and localization of knee joint effusion in rheumatoid arthritis","volume":"30","author":"Kane","year":"2003","journal-title":"J Rheumatol"},{"key":"2025021211251274000_40.3.244.8","doi-asserted-by":"publisher","DOI":"10.1002\/art.20054"},{"key":"2025021211251274000_40.3.244.9","doi-asserted-by":"publisher","DOI":"10.1002\/art.20333"},{"key":"2025021211251274000_40.3.244.10","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.023929"},{"key":"2025021211251274000_40.3.244.11","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.227"},{"key":"2025021211251274000_40.3.244.12","doi-asserted-by":"publisher","DOI":"10.1002\/art.10877"},{"key":"2025021211251274000_40.3.244.13","doi-asserted-by":"publisher","DOI":"10.1002\/art.20123"},{"key":"2025021211251274000_40.3.244.14","unstructured":"Dougados M Devauchelle-Pensec V Ferlet JF Jousse-Joulin S D\u2019Agostino MA Backhaus M The ability of synovitis to predict structural damage in rheumatoid arthritis: A comparative study between clinical examination and ultrasound. Ann Rheum Dis 2012 Jun 7. [E-pub ahead of print]"},{"key":"2025021211251274000_40.3.244.15","doi-asserted-by":"publisher","DOI":"10.1002\/art.21544"},{"key":"2025021211251274000_40.3.244.16","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.1.55"},{"key":"2025021211251274000_40.3.244.17","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2292020206"},{"key":"2025021211251274000_40.3.244.18","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.044628"},{"key":"2025021211251274000_40.3.244.19","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.025585"},{"key":"2025021211251274000_40.3.244.20","first-page":"35","article-title":"Clinical and ultrasonographic monitoring of response to adalimumab treatment in rheumatoid arthritis","volume":"35","author":"Iagnocco","year":"2008","journal-title":"J Rheumatol"},{"key":"2025021211251274000_40.3.244.21","first-page":"2485","article-title":"Musculoskeletal ultrasound including definitions for ultrasonographic pathology","volume":"32","author":"Wakefield","year":"2005","journal-title":"J Rheumatol"},{"key":"2025021211251274000_40.3.244.22","first-page":"848","article-title":"The OMERACT Ultrasound Group: Status of current activities and research directions","volume":"34","author":"Wakefield","year":"2007","journal-title":"J Rheumatol"},{"key":"2025021211251274000_40.3.244.23","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.015081"},{"key":"2025021211251274000_40.3.244.24","first-page":"881","article-title":"Ultrasonography assessment of inflammatory activity in rheumatoid arthritis: Comparison of extended versus reduced joint evaluation","volume":"23","author":"Naredo","year":"2005","journal-title":"Clin Exp Rheumatol"},{"key":"2025021211251274000_40.3.244.25","doi-asserted-by":"publisher","DOI":"10.1002\/art.23529"},{"key":"2025021211251274000_40.3.244.26","doi-asserted-by":"publisher","DOI":"10.1002\/art.24646"},{"key":"2025021211251274000_40.3.244.27","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"2025021211251274000_40.3.244.28","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090881"},{"key":"2025021211251274000_40.3.244.29","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090879"},{"key":"2025021211251274000_40.3.244.30","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20175"},{"key":"2025021211251274000_40.3.244.31","first-page":"839","article-title":"Summary findings of a systematic review of the ultrasound assessment of synovitis","volume":"34","author":"Joshua","year":"2007","journal-title":"J Rheumatol"},{"key":"2025021211251274000_40.3.244.32","first-page":"632","article-title":"Relationship between clinically detected joint swelling and effusion diagnosed by ultrasonography in metatarsophalangeal and talocrural joints in patients with rheumatoid arthritis","volume":"21","author":"Luukkainen","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"2025021211251274000_40.3.244.33","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0402-3"},{"key":"2025021211251274000_40.3.244.34","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-004-1010-8"},{"key":"2025021211251274000_40.3.244.35","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.115493"},{"key":"2025021211251274000_40.3.244.36","doi-asserted-by":"publisher","DOI":"10.1186\/ar3341"},{"key":"2025021211251274000_40.3.244.37","doi-asserted-by":"publisher","DOI":"10.1002\/art.22190"},{"key":"2025021211251274000_40.3.244.38","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110424"},{"key":"2025021211251274000_40.3.244.39","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.10.895"},{"key":"2025021211251274000_40.3.244.40","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200109)44:9<2018::AID-ART350>3.0.CO;2-C"},{"key":"2025021211251274000_40.3.244.41","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.8.770"},{"key":"2025021211251274000_40.3.244.42","doi-asserted-by":"publisher","DOI":"10.1002\/art.33312"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.120843","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T19:25:48Z","timestamp":1739388348000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.120843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,15]]},"references-count":42,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,1]]},"published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.3899\/jrheum.120843"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.120843","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"type":"print","value":"0315-162X"},{"type":"electronic","value":"1499-2752"}],"subject":[],"published":{"date-parts":[[2013,1,15]]}}}