{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T18:05:45Z","timestamp":1773857145024,"version":"3.50.1"},"reference-count":38,"publisher":"The Journal of Rheumatology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"accepted":{"date-parts":[[2012,10,29]]},"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To evaluate homocysteine levels in patients with Takayasu arteritis (TA) and in controls, and to analyze associations between homocysteine levels and paraoxonase 1 (PON1) activity, cysteine levels, methotrexate use, disease activity, extent of arterial involvement, and ischemic events in patients with TA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>A cross-sectional study was performed with 29 patients with TA and 30 controls who underwent clinical evaluation and blood sample collection in the fasting state.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Among patients with TA, active disease was observed in 9 (31.0%) and previous arterial ischemic events in 10 (34.5%). Therapy with methotrexate was prescribed to 9 (31.0%) patients and it was associated with folic acid in 8 cases. Median homocysteine level was higher in patients with TA [10.9 \u03bcmol\/l, interquartile range (IQR) 9.6\u201314.8] than in controls (6.9 \u03bcmol\/l, IQR 5.1\u201311.9; p &lt; 0.001). No difference was found regarding mean homocysteine levels between those using methotrexate and those under other therapies (12.8 \u00b1 5.3 \u03bcmol\/l vs 12.1 \u00b1 3.2 \u03bcmol\/l, respectively; p = 0.662). TA patients with active disease presented lower homocysteine levels (10.4 \u00b1 2.1 \u03bcmol\/l) compared to TA patients in remission (13.1 \u00b1 4.2 \u03bcmol\/l) (p = 0.034). A significant correlation was found between cysteine and homocysteine levels in patients with TA (\u03c1 = 0.676, p &lt; 0.0001), while there was no correlation between homocysteine and PON1 activity (\u03c1 = 0.214, p = 0.265). Median homocysteine levels were higher in patients with ischemic events (13.2 \u03bcmol\/l, IQR 10.9\u201317.5) compared to patients with no ischemic events (9.8 \u03bcmol\/l, IQR 8.7\u201314.7; p = 0.027) and were associated with arterial ischemia in patients with TA (OR 1.31, 95% CI 1.01\u20131.71, p = 0.041).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Patients with TA presented higher homocysteine levels than controls and homocysteine was associated with an increased risk of arterial ischemic events in TA.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.121073","type":"journal-article","created":{"date-parts":[[2012,12,16]],"date-time":"2012-12-16T02:54:48Z","timestamp":1355626488000},"page":"303-308","source":"Crossref","is-referenced-by-count":13,"title":["Homocysteine Levels in Takayasu Arteritis \u2014 A Risk Factor for Arterial Ischemic Events"],"prefix":"10.3899","volume":"40","author":[{"given":"ALEXANDRE WAGNER SILVA","family":"DE 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