{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T20:51:17Z","timestamp":1764276677933},"reference-count":30,"publisher":"The Journal of Rheumatology","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To examine differences in number and size of signal hyperintensities (SH) on magnetic resonance imaging (MRI) between patients with primary Sj\u00f6gren syndrome (pSS) and controls who all had frequent episodic tension-type headache (FETH), and to investigate their relation to platelet serotonin level (PSL), patient age, disease duration, and activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>SH in 22 pSS patients with FETH were compared to 20 aged-matched controls with FETH, using the modified semiquantitative rating scale. Spectrofluorimetry was used for determination of PSL, and the European League Against Rheumatism SS Disease Activity Index (ESSDAI) for disease activity assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Statistically significant differences in the total number of SH were noted infratentorially (p = 0.025) and in the basal ganglia for lesions of diameter &gt; 5 mm (p = 0.048). Significant correlations were found between disease duration and number of overall lesions &gt; 5 mm (p = 0.04) and subcortical lesions of diameter 2\u20135 mm (p = 0.035). Number of periventricular SH inversely correlated to PSL (p = 0.019) and to patient age (p = 0.004), without association with markers of immunoinflammation and ESSDAI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Our study showed that SH on brain MRI are more common in specific regions of the brain in pSS patients with FETH than in controls with FETH, signifying a more widespread cerebral vasculopathy in SS patients with FETH. Periventricular SH seem to be associated to increased platelet serotonin release in pSS patients with FETH and correlated with disease duration, without correlation to the actual ESSDAI and markers of immunoinflammation, and might be linked with chronic immunoinflammation of low-grade intensity and vasculitis in pSS.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.121132","type":"journal-article","created":{"date-parts":[[2013,6,2]],"date-time":"2013-06-02T00:49:20Z","timestamp":1370134160000},"page":"1360-1366","source":"Crossref","is-referenced-by-count":9,"title":["Signal Hyperintensities on Brain Magnetic Resonance Imaging in Patients with Primary Sj\u00f6gren Syndrome and Frequent Episodic Tension-type Headache: Relation to Platelet Serotonin Level and Disease Activity"],"prefix":"10.3899","volume":"40","author":[{"given":"Helena","family":"\u0160arac","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasenka","family":"Markeljevi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktorija","family":"Erdelji\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeljka","family":"Josipovi\u0107-Jeli\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanja","family":"Hajn\u0161ek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"Klapan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Batinica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Bar\u0161i\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jadranka","family":"Serti\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Dobrila Dintinjana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2013,6,1]]},"reference":[{"key":"2018112909320986000_40.8.1360.1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/01.md.0000141099.53742.16","article-title":"Neurologic manifestations in primary Sj\u00f6gren syndrome: A study of 82 patients","volume":"83","author":"Delalande","year":"2004","journal-title":"Medicine"},{"key":"2018112909320986000_40.8.1360.2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.019497"},{"key":"2018112909320986000_40.8.1360.3","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-108-6-815"},{"key":"2018112909320986000_40.8.1360.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2004.07.005"},{"key":"2018112909320986000_40.8.1360.5","first-page":"368","article-title":"Central and peripheral neurologic lesions in primary Gougerot-Sj\u00f6gren syndrome. 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