{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:36:36Z","timestamp":1781523396793,"version":"3.54.1"},"reference-count":50,"publisher":"The Journal of Rheumatology","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To evaluate the outcome of tumor necrosis factor-\u03b1 inhibition (anti-TNF) for pediatric uveitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We retrospectively assessed children (age \u2264 18 yrs) with noninfectious uveitis receiving anti-TNF at 5 uveitis centers and 1 pediatric rheumatology center. Incident treatment success was defined as minimal or no uveitis activity at \u2265 2 consecutive ophthalmological examinations \u2265 28 days apart while taking no oral and \u2264 2 eyedrops\/day of corticosteroids. Eligible children had active uveitis and\/or were taking higher corticosteroid doses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Among 56 eligible children followed over 33.73 person-years, 52% had juvenile idiopathic arthritis (JIA) and 75% had anterior uveitis (AU). The Kaplan-Meier estimated proportion achieving treatment success within 12 months was 75% (95% CI 62%\u201387%). Complete absence of inflammatory signs with discontinuation of all corticosteroids was observed in an estimated 64% by 12 months (95% CI 51%\u201376%). Diagnoses of JIA or AU were associated with greater likelihood of success, as was the oligoarticular subtype among JIA cases. In a multivariable model, compared to those with JIA-associated AU, those with neither or with JIA or AU alone had a 75%\u201380% lower rate of achieving quiescence under anti-TNF, independent of the number of immunomodulators previously or concomitantly prescribed. Uveitis reactivated within 12 months of achieving quiescence in 14% of those continuing anti-TNF (95% CI 6%\u201331%). The incidence of discontinuation for adverse effects was 8%\/year (95% CI 1%\u201343%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Treatment with anti-TNF was successful and sustained in a majority of children with noninfectious uveitis, and treatment-limiting toxicity was infrequent. JIA-associated AU may be especially responsive to anti-TNF.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.121180","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T01:50:49Z","timestamp":1372729849000},"page":"1394-1403","source":"Crossref","is-referenced-by-count":63,"title":["Response of Pediatric Uveitis to Tumor Necrosis Factor-\u03b1 Inhibitors"],"prefix":"10.3899","volume":"40","author":[{"given":"Melissa A.","family":"Lerman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon M.","family":"Burnham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Y.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebenezer","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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