{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:12:58Z","timestamp":1790363578242,"version":"4.1.0"},"reference-count":29,"publisher":"The Journal of Rheumatology","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To examine the efficacy and safety of antibiotic treatments for reactive arthritis (ReA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We did a systematic review and metaanalysis of randomized controlled trials of antibiotics for treatment of ReA. We searched electronic databases and conference proceedings up to November 2011. Included trials reported on remission, joint counts, and pain or patient global scores in any language.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Twelve trials were eligible for inclusion and 10 provided data for metaanalysis. The pooled relative risk of failure to achieve remission from a random effects model showed no significant benefit of antibiotic treatment on remission (7 trials, 375 participants, RR 0.74, 95% CI 0.49\u20131.10); however, substantial heterogeneity was observed (I<jats:sup>2<\/jats:sup> = 76.3%, p &lt; 0.0001). The treatment effect did not differ significantly by the type of organism triggering the ReA (chlamydia, 4 trials, RR 0.80, 95% CI 0.63\u20131.03, vs other microorganisms, 5 trials, RR 0.72, 95% CI 0.29\u20131.79, metaregression p = 0.477) or use of combination antibiotics (monotherapy, 6 trials, RR 0.70, 95% CI 0.39\u20131.26, vs combination therapy, 1 trial, RR 0.79, 95% CI 0.63\u20130.99, metaregression p = 0.466). When unblinded trials were excluded, the treatment effect was attenuated and heterogeneity decreased (RR 0.87, 95% CI 0.70\u20131.10, I<jats:sup>2<\/jats:sup> = 32.8%, p = 0.19). No significant effects of antibiotic treatment were observed on joint counts, pain, or patient global scores; however, antibiotics were associated with a 97% increase in gastrointestinal adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Trials of antibiotic treatment for ReA have produced heterogeneous results that may be related to differences in study design. The efficacy of antibiotics is uncertain.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.121192","type":"journal-article","created":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T22:13:15Z","timestamp":1366063995000},"page":"916-928","source":"Crossref","is-referenced-by-count":63,"title":["Antibiotics for Treatment of Reactive Arthritis: A Systematic Review and Metaanalysis"],"prefix":"10.3899","volume":"40","author":[{"given":"Claire E.","family":"Barber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Inman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Esdaile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2013,4,15]]},"reference":[{"key":"2018112909313806000_40.6.916.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2006.02.003"},{"key":"2018112909313806000_40.6.916.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2009.03.010"},{"key":"2018112909313806000_40.6.916.3","doi-asserted-by":"publisher","DOI":"10.1080\/03009740500202540"},{"key":"2018112909313806000_40.6.916.4","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32833a43a2"},{"key":"2018112909313806000_40.6.916.5","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/art.1780350613","article-title":"Yersinia-triggered reactive arthritis. Use of polymerase chain reaction and immunocytochemical staining in the detection of bacterial components from synovial specimens","volume":"35","author":"Nikkari","year":"1992","journal-title":"Arthritis Rheum"},{"key":"2018112909313806000_40.6.916.6","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199901)42:1<84::AID-ANR11>3.0.CO;2-C"},{"key":"2018112909313806000_40.6.916.7","doi-asserted-by":"publisher","DOI":"10.1002\/art.27394"},{"key":"2018112909313806000_40.6.916.8","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.045484"},{"key":"2018112909313806000_40.6.916.9","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.010710"},{"key":"2018112909313806000_40.6.916.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.005"},{"key":"2018112909313806000_40.6.916.11","doi-asserted-by":"crossref","unstructured":"Egger M Smith GD Altman DG . Systematic reviews in health care: Meta-analysis in context. 2nd ed. London: BMJ; 2001.","DOI":"10.1002\/9780470693926"},{"key":"2018112909313806000_40.6.916.12","first-page":"393","article-title":"Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis","volume":"37","author":"Ritchie","year":"1968","journal-title":"Q J Med"},{"key":"2018112909313806000_40.6.916.13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"2018112909313806000_40.6.916.14","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"2018112909313806000_40.6.916.15","unstructured":"Higgins JPT Green S , editors. Cochrane handbook for systematic reviews of interventions, Version 5.1.0, updated March 2011. The Cochrane Collaboration, 2011. [Internet. Accessed Feb 14, 2013.] Available from: www.cochrane-handbook.org"},{"key":"2018112909313806000_40.6.916.16","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"2018112909313806000_40.6.916.17","first-page":"515","article-title":"Efficacy of empirically prescribed amoxicillin and amoxicillin + clavulanic acid in children\u2019s reactive arthritis: A randomised trial","volume":"21","author":"Astrauskiene","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"2018112909313806000_40.6.916.18","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.301.6764.1299"},{"key":"2018112909313806000_40.6.916.19","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.11.914"},{"key":"2018112909313806000_40.6.916.20","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340103"},{"key":"2018112909313806000_40.6.916.21","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199907)42:7<1386::AID-ANR12>3.0.CO;2-E"},{"key":"2018112909313806000_40.6.916.22","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.12.1088"},{"key":"2018112909313806000_40.6.916.23","first-page":"301","article-title":"Effect of antimicrobial treatment on chronic reactive arthritis","volume":"11","author":"Toivanen","year":"1993","journal-title":"Clin Exp Rheumatol"},{"key":"2018112909313806000_40.6.916.24","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199909)42:9<1894::AID-ANR14>3.0.CO;2-V"},{"key":"2018112909313806000_40.6.916.25","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.7.565"},{"key":"2018112909313806000_40.6.916.26","doi-asserted-by":"publisher","DOI":"10.2174\/138955712798868977"},{"key":"2018112909313806000_40.6.916.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2007.11.001"},{"key":"2018112909313806000_40.6.916.28","doi-asserted-by":"publisher","DOI":"10.2174\/1874467210801010068"},{"key":"2018112909313806000_40.6.916.29","first-page":"2112","article-title":"Should tetracycline treatment be used more extensively for rheumatoid arthritis? Metaanalysis demonstrates clinical benefit with reduction in disease activity","volume":"30","author":"Stone","year":"2003","journal-title":"J Rheumatol"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.121192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T13:24:50Z","timestamp":1543497890000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.121192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,15]]},"references-count":29,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,6,1]]},"published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.3899\/jrheum.121192"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.121192","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,15]]}}}