{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:37:56Z","timestamp":1793151476587,"version":"4.5.0"},"reference-count":41,"publisher":"The Journal of Rheumatology","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>We investigated associations of HLA-B27 with clinical manifestations and longterm outcome in a near population-based setting among patients with juvenile idiopathic arthritis (JIA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We studied clinical and serological data from 410 patients with HLA-B27 results among 440 prospectively collected patients with JIA with 8-year followup data in a Nordic database. The study was structured to be as close to a population-based study as possible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>HLA-B27 was analyzed in 93% of patients, and was positive in 21% of the cohort, in 18.4% of the girls and in 25.9% of the boys. Boys who were HLA-B27-positive had significantly higher age at onset compared to HLA-B27-negative boys and compared to both HLA-B27-negative and positive girls. This difference in onset age in relation to HLA-B27 was not found in girls. HLA-B27 was associated with clinical signs of sacroiliitis, enthesitis, and tenosynovitis in boys, but not in girls. After 8 years of disease, 46 children (11.2%) were classified as having enthesitis-related arthritis (ERA). Boys with ERA had clinical signs of sacroiliitis more often than girls with ERA. HLA-B27-positive children, as well as children with clinical signs of sacroiliitis, enthesitis, and hip arthritis, had higher odds of not being in remission off medication after 8 years of disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>In this near population-based Nordic JIA cohort we found significant differences between HLA-B27-positive boys and girls in age at disease onset, clinical signs of sacroiliitis, and ERA classification. HLA-B27 was negatively associated with longterm remission status, possibly because of its association with clinical disease characteristics, such as sacroiliitis, rather than being a general marker of persistent disease.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.121257","type":"journal-article","created":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T20:59:34Z","timestamp":1364849974000},"page":"725-731","source":"Crossref","is-referenced-by-count":67,"title":["HLA-B27 Predicts a More Chronic Disease Course in an 8-year Followup Cohort of Patients with Juvenile Idiopathic Arthritis"],"prefix":"10.3899","volume":"40","author":[{"given":"Lillemor","family":"Berntson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Nordal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristiina","family":"Aalto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvi","family":"Peltoniemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troels","family":"Herlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Zak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marite","family":"Rygg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Nordic Study Group of Paediatric Rheumatology","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2013,4,1]]},"reference":[{"key":"2018112909313174000_40.5.725.1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.103"},{"key":"2018112909313174000_40.5.725.2","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty","year":"2004","journal-title":"J Rheumatol"},{"key":"2018112909313174000_40.5.725.3","first-page":"192","article-title":"Axial involvement in the seronegative enthesopathy and arthropathy syndrome and its progression to ankylosing spondylitis","volume":"16","author":"Burgos-Vargas","year":"1989","journal-title":"J Rheumatol"},{"key":"2018112909313174000_40.5.725.4","doi-asserted-by":"publisher","DOI":"10.1002\/art.22181"},{"key":"2018112909313174000_40.5.725.5","first-page":"1122","article-title":"Early disease course and predictors of disability in juvenile rheumatoid arthritis and juvenile spondyloarthropathy: A 3 year prospective study","volume":"32","author":"Selvaag","year":"2005","journal-title":"J Rheumatol"},{"key":"2018112909313174000_40.5.725.6","first-page":"308","article-title":"The natural history of juvenile chronic arthritis: A population based cohort study. 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