{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T09:43:05Z","timestamp":1749807785597},"reference-count":22,"publisher":"The Journal of Rheumatology","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To quantify the independent role of each of low-density lipoprotein cholesterol (LDL-C), total cholesterol:high-density lipoprotein cholesterol ratio (TC:HDL-C), triglyceride (TG) level, and HDL-C as a marker of coronary risk in systemic lupus erythematosus (SLE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Patients with lipid measurements taken before a coronary event (or last clinic visit) were included. Mean and time-adjusted mean (TAM) levels were calculated for each lipid variable in each patient. Time-dependent proportional hazards regression models were used to quantify the risk of coronary event [myocardial infarction (MI) or angina], after adjustment for age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Among 384 patients, over a mean (SD) followup of 3.81 (2.58) years, there were 21 \u201cfirst\u201d coronary events (6 MI, 15 angina). Mean and TAM LDL-C (HR 1.83, 95% CI 1.19\u20132.81, p = 0.006), TC:HDL ratio (HR 1.43, 95% CI 1.02\u20132.00, p = 0.04), and TG (HR 2.11, 95% CI 1.32\u20133.39, p = 0.0019) were predictive of coronary event at subsequent visits. In contingency table analysis, TAM LDL-C cutpoint of 2.0 mmol\/l had a sensitivity and negative predictive value for coronary event of 85.7% (95% CI 63.7\u201397.0) and 93.9% (95% CI 83.1\u201398.7), respectively. However, at this cutpoint the specificity was only 12.7% (95% CI 9.4\u201316.5).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>This study links LDL-C, TC:HDL-C ratio, and TG to coronary risk in patients with SLE and quantifies the magnitude of this risk. SLE-specific risk assessment levels for lipids may be selected to optimize positive or negative predictive values.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.121273","type":"journal-article","created":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T04:32:27Z","timestamp":1381897947000},"page":"2006-2014","source":"Crossref","is-referenced-by-count":6,"title":["Assessment of Coronary Risk Based on Cumulative Exposure to Lipids in Systemic Lupus Erythematosus"],"prefix":"10.3899","volume":"40","author":[{"given":"Mandana","family":"Nikpour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dafna D.","family":"Gladman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Ibanez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula J.","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray B.","family":"Urowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2013,10,15]]},"reference":[{"key":"2018112909321461000_40.12.2006.1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-009-0035-z"},{"key":"2018112909321461000_40.12.2006.2","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1161\/circ.106.25.3143","article-title":"Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report","volume":"106","year":"2002","journal-title":"Circulation"},{"key":"2018112909321461000_40.12.2006.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000133317.49796.0E"},{"key":"2018112909321461000_40.12.2006.4","doi-asserted-by":"publisher","DOI":"10.1186\/ar3063"},{"key":"2018112909321461000_40.12.2006.5","doi-asserted-by":"publisher","DOI":"10.1186\/ar3473"},{"key":"2018112909321461000_40.12.2006.6","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin Chem"},{"key":"2018112909321461000_40.12.2006.7","doi-asserted-by":"publisher","DOI":"10.1002\/art.11264"},{"key":"2018112909321461000_40.12.2006.8","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90151-1"},{"key":"2018112909321461000_40.12.2006.9","first-page":"824","article-title":"Adjusted mean Systemic Lupus Erythematosus Disease Activity Index-2K is a predictor of outcome in SLE","volume":"32","author":"Ibanez","year":"2005","journal-title":"J Rheumatol"},{"key":"2018112909321461000_40.12.2006.10","doi-asserted-by":"publisher","DOI":"10.1161\/hc4101.097518"},{"key":"2018112909321461000_40.12.2006.11","doi-asserted-by":"publisher","DOI":"10.1177\/096120339700600610"},{"key":"2018112909321461000_40.12.2006.12","doi-asserted-by":"publisher","DOI":"10.1002\/art.20630"},{"key":"2018112909321461000_40.12.2006.13","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.13.1937"},{"key":"2018112909321461000_40.12.2006.14","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(83)90174-6"},{"key":"2018112909321461000_40.12.2006.15","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(77)90874-9"},{"key":"2018112909321461000_40.12.2006.16","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(91)90007-8"},{"key":"2018112909321461000_40.12.2006.17","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e3282364a17"},{"key":"2018112909321461000_40.12.2006.18","doi-asserted-by":"publisher","DOI":"10.1002\/art.21976"},{"key":"2018112909321461000_40.12.2006.19","doi-asserted-by":"publisher","DOI":"10.1002\/art.24677"},{"key":"2018112909321461000_40.12.2006.20","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.136762"},{"key":"2018112909321461000_40.12.2006.21","doi-asserted-by":"publisher","DOI":"10.1186\/ar3402"},{"key":"2018112909321461000_40.12.2006.22","first-page":"1441","article-title":"Recommendations for the management and treatment of dyslipidemia. 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