{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:26:14Z","timestamp":1787617574398,"version":"build-2736575974"},"reference-count":42,"publisher":"The Journal of Rheumatology","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective.<\/jats:title>\n                    <jats:p>To assess the added effect of comorbidity on quality of life (QOL) in psoriatic arthritis (PsA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>Between 2006 and 2012, 631 patients were recruited from the University of Toronto PsA Clinic. Using the clinical database, we ascertained the frequency of 15 comorbidities. The Medical Outcomes Study Short Form-36 (SF-36) physical (PCS) and mental component (MCS) summary scales were used to assess QOL. Linear regression analyses were conducted to estimate the magnitude of the association between number and type of comorbidities and PCS and MCS scores, after adjustment for disease-related and sociodemographic variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>\n                      Prevalence of comorbidity was high, with 42% of patients having 3 or more comorbid conditions. After adjustment for inflammatory disease\u2013related and sociodemographic factors, a history of 3 or more comorbid conditions accounted for only 2% and 1% of the R\n                      <jats:sup>2<\/jats:sup>\n                      value explained in PCS and MCS scores, respectively. In terms of added burden, type of comorbid condition was more significant than number of comorbidities. After adjustment for disease-related and sociodemographic factors, fibromyalgia (FM), neurological disorders, and obesity jointly accounted for 6% of R\n                      <jats:sup>2<\/jats:sup>\n                      value explained in PCS scores, while FM and depression\/anxiety jointly accounted for about 9% of the R\n                      <jats:sup>2<\/jats:sup>\n                      explained in MCS scores. The point decrease in PCS and MCS scores associated with each of these disorders was clinically significant. The 11 other comorbid conditions failed to achieve statistical significance in the models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>The added effect of comorbidity on patient-reported physical and mental health in PsA was more related to type of comorbidity than number of comorbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3899\/jrheum.121500","type":"journal-article","created":{"date-parts":[[2013,6,15]],"date-time":"2013-06-15T20:21:30Z","timestamp":1371327690000},"page":"1349-1356","source":"Crossref","is-referenced-by-count":96,"title":["Incremental Effects of Comorbidity on Quality of Life in Patients with Psoriatic Arthritis"],"prefix":"10.3899","volume":"40","author":[{"given":"Janice A.","family":"Husted","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arane","family":"Thavaneswaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Chandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafna D.","family":"Gladman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2013,6,15]]},"reference":[{"key":"2018112909320979000_40.8.1349.1","doi-asserted-by":"crossref","unstructured":"Gladman DD . Psoriatic arthritis. In: Harris ED Budd RC Firestein GS Genovese MC Sergent JS Ruddy S editors. Kelly\u2019s textbook of rheumatology. 7th ed. Philadelphia: W.B. Saunders Co.; 2004:1155\u201364.","DOI":"10.1111\/j.1396-0296.2004.04038.x"},{"key":"2018112909320979000_40.8.1349.2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-012-8302-6"},{"key":"2018112909320979000_40.8.1349.3","first-page":"127","article-title":"Psoriatic arthritis (PSA) \u2014 an analysis of 220 patients","volume":"62","author":"Gladman","year":"1987","journal-title":"Q J Med"},{"key":"2018112909320979000_40.8.1349.4","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200104)45:2<151::AID-ANR168>3.0.CO;2-T"},{"key":"2018112909320979000_40.8.1349.5","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg384"},{"key":"2018112909320979000_40.8.1349.6","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg217"},{"key":"2018112909320979000_40.8.1349.7","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.1.68"},{"key":"2018112909320979000_40.8.1349.8","first-page":"1842","article-title":"Comparison of disability and quality of life in rheumatoid and psoriatic arthritis","volume":"28","author":"Sokoll","year":"2001","journal-title":"J Rheumatol"},{"key":"2018112909320979000_40.8.1349.9","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0298-y"},{"key":"2018112909320979000_40.8.1349.10","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-7-25"},{"key":"2018112909320979000_40.8.1349.11","first-page":"680","article-title":"The burden of psoriatic arthritis: a literature review from a global health systems perspective","volume":"35","author":"Lee","year":"2010","journal-title":"Pharm Therapeut"},{"key":"2018112909320979000_40.8.1349.12","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.092049"},{"key":"2018112909320979000_40.8.1349.13","doi-asserted-by":"publisher","DOI":"10.1080\/00015550252948130"},{"key":"2018112909320979000_40.8.1349.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2008.10.005"},{"key":"2018112909320979000_40.8.1349.15","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/acr.20627","article-title":"Cardiovascular and other comorbidities in patients with psoriatic arthritis: a comparison with patients with psoriasis","volume":"63","author":"Husted","year":"2011","journal-title":"Arthritis Care Res"},{"key":"2018112909320979000_40.8.1349.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2006.09.001"},{"key":"2018112909320979000_40.8.1349.17","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken090"},{"key":"2018112909320979000_40.8.1349.18","first-page":"2167","article-title":"Cardiovascular disease and risk factors in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis","volume":"33","author":"Han","year":"2006","journal-title":"J Rheumatol"},{"key":"2018112909320979000_40.8.1349.19","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200809020-00004"},{"key":"2018112909320979000_40.8.1349.20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03463.x"},{"key":"2018112909320979000_40.8.1349.21","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-010-0112-3"},{"key":"2018112909320979000_40.8.1349.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.01.006"},{"key":"2018112909320979000_40.8.1349.23","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.094839"},{"key":"2018112909320979000_40.8.1349.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2004.07.010"},{"key":"2018112909320979000_40.8.1349.25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2010.02310.x"},{"key":"2018112909320979000_40.8.1349.26","doi-asserted-by":"publisher","DOI":"10.2165\/11530640-000000000-00000"},{"key":"2018112909320979000_40.8.1349.27","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-004-0616-2"},{"key":"2018112909320979000_40.8.1349.28","doi-asserted-by":"publisher","DOI":"10.2307\/3350223"},{"key":"2018112909320979000_40.8.1349.29","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.10.1180"},{"key":"2018112909320979000_40.8.1349.30","doi-asserted-by":"publisher","DOI":"10.1586\/17469872.3.4s.S35"},{"key":"2018112909320979000_40.8.1349.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.08.023"},{"key":"2018112909320979000_40.8.1349.32","doi-asserted-by":"publisher","DOI":"10.1002\/art.21972"},{"key":"2018112909320979000_40.8.1349.33","doi-asserted-by":"publisher","DOI":"10.1002\/art.23104"},{"key":"2018112909320979000_40.8.1349.34","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"2018112909320979000_40.8.1349.35","doi-asserted-by":"publisher","DOI":"10.1002\/art.23185"},{"key":"2018112909320979000_40.8.1349.36","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1989.01670140087017"},{"key":"2018112909320979000_40.8.1349.37","unstructured":"Ware JE Kosinski M Keller SD . SF-36 physical and mental health summary scales: a user manual. 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