{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:02:17Z","timestamp":1780470137390,"version":"3.54.1"},"reference-count":20,"publisher":"The Journal of Rheumatology","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Factors that predispose patients to <jats:italic>Chlamydia<\/jats:italic>-induced reactive arthritis (CiReA) are poorly defined. Data indirectly suggest chemokine receptor-5 (CCR5)-delta-32 mutation might play a role in CiReA. We investigated the attack rate of CiReA and we hypothesized that the CCR5-delta-32 allele may modulate disease susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Patients who tested positive for <jats:italic>Chlamydia trachomatis<\/jats:italic> after either (1) symptoms of an acute venereal disease or (2) sexual contact with an individual known to be positive for the same organism were followed in a prospective fashion. All patients were contacted at Week 6 after their acute infection and queried for symptoms of CiReA. Patients who had new-onset symptoms suggestive of CiReA were followed at Weeks 12, 26, and 52. All subjects were tested for CCR5-delta-32 mutation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>A total of 365 study participants were enrolled, with average age 24.4 years, 201 men (55%) and 164 women (45%). We followed up with 149 patients (41%) at Week 6. Twelve of 149 participants (8.1%) had symptoms suggestive of CiReA at Week 6. None of these 12 patients was positive for the CCR5-delta-32 mutation. Of the 12 patients that had symptoms at Week 6, we were able to follow up with 7 through Week 52. All 7 had complete resolution of their symptoms by Week 26. Overall, 25\/365 (6.8%) subjects were positive for the CCR5-delta-32 mutation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>The attack rate of CiReA in our study was higher than previously reported, but the CCR5-delta-32 mutation does not seem to play a role in CiReA disease susceptibility.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.130136","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T01:50:49Z","timestamp":1372729849000},"page":"1578-1582","source":"Crossref","is-referenced-by-count":12,"title":["Attack Rate of <i>Chlamydia<\/i>-induced Reactive Arthritis and Effect of the CCR5-Delta-32 Mutation: A Prospective Analysis"],"prefix":"10.3899","volume":"40","author":[{"given":"John 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