{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:25:33Z","timestamp":1790803533105,"version":"4.1.0"},"reference-count":42,"publisher":"The Journal of Rheumatology","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Human endogenous retrovirus (HERV)-K10 has been implicated in the etiology and pathogenesis of rheumatoid arthritis (RA). A secondary immune response to this virus might suggest an antigen-driven response in patients. The Gag region of HERV-K10 could provide a key epitope important for immunological reactivity. We investigated the presence of IgG antibodies to this region and assessed its significance in RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We determined an antigenic peptide on the matrix segment of HERV-K10 and developed an ELISA system to detect IgG antibodies in patients with RA and controls. The presence of antibodies to the matrix peptide (denoted as MAG1: RIGKELKQAGRKGNI) was correlated with patient details.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>On screening patients\u2019 serum, we found a significantly higher mean IgG antibody response to MAG1 in 30 patients with RA as compared to 23 patients with inflammatory bowel disease (p = 0.003), 29 patients with osteoarthritis (p = 0.001), and 43 healthy individuals (p = 0.002). Reactivity was not observed to a control peptide possessing a nonhomologous amino acid sequence. On evaluating clinical details with serological activity, no correlation with disease duration (p = 0.128), sex (p = 0.768), or rheumatoid factor status (p = 0.576) was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>A significantly elevated IgG antibody response to an HERV-K10 Gag matrix peptide was observed in patients with RA, suggesting that the exposure of HERV-K10 may cause a secondary, antigenic driven immune response in RA.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.130502","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T06:50:36Z","timestamp":1410850236000},"page":"1952-1960","source":"Crossref","is-referenced-by-count":46,"title":["Rheumatoid Arthritis is Associated with IgG Antibodies to Human Endogenous Retrovirus Gag Matrix: A Potential Pathogenic Mechanism of Disease?"],"prefix":"10.3899","volume":"41","author":[{"given":"Paul N.","family":"Nelson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Roden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Nevill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham L.","family":"Freimanis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Trela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hora Davari","family":"Ejtehadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Bowman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Axford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy M.","family":"Veitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Tugnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul B.","family":"Rylance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2014,9,15]]},"reference":[{"key":"2018112909333012000_41.10.1952.1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01661"},{"key":"2018112909333012000_41.10.1952.2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei228"},{"key":"2018112909333012000_41.10.1952.3","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcp165"},{"key":"2018112909333012000_41.10.1952.4","doi-asserted-by":"publisher","DOI":"10.1053\/sarh.2000.16527"},{"key":"2018112909333012000_41.10.1952.5","doi-asserted-by":"publisher","DOI":"10.2174\/156652409789839134"},{"key":"2018112909333012000_41.10.1952.6","first-page":"1","article-title":"Pathogenesis and spectrum of autoimmunity","volume":"102","author":"Perl","year":"2004","journal-title":"Methods Mol Med"},{"key":"2018112909333012000_41.10.1952.7","first-page":"29","article-title":"Human endogenous retrovirus HERV-K10 implicated in rheumatoid arthritis and systemic lupus erythematosus: potential pathological triggers?","volume":"150","author":"Nelson","year":"2006","journal-title":"Biomed Pap"},{"key":"2018112909333012000_41.10.1952.8","doi-asserted-by":"crossref","unstructured":"Nelson PN Freimanis G Roden D . 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