{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:56:26Z","timestamp":1761155786918},"reference-count":17,"publisher":"The Journal of Rheumatology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Rheumatoid factor-positive polyarthritis (RF+ poly) is the juvenile idiopathic arthritis (JIA) category that resembles adult seropositive rheumatoid arthritis (RA). We studied children with RF+ and\/or anticyclic citrullinated peptide antibody (anti-CCP)+ JIA to determine what proportion of those children meet International League of Associations for Rheumatology (ILAR) criteria for RF+ poly JIA and to assess for significant differences between children who meet RF+ poly criteria and those who are classified in other categories.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Charts of children with JIA who were RF+ and\/or anti-CCP+ were reviewed. Children with RF+ poly JIA were compared to children in other categories. Statistical analysis was performed using chi-square, Fisher\u2019s exact test, and the Student\u2019s t-test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Of 56 children with RF+ and\/or anti-CCP+ JIA, 34 (61%) met ILAR criteria for RF+ poly JIA. Twelve children had RF\u2013\/anti-CCP+ JIA with low anti-CCP titers. When these 12 children were excluded, there were few significant differences between children who met criteria for RF+ poly and those who were classified in other categories. The American College of Rheumatology\/European League Against Rheumatism criteria for RA identified more RF+ children than did the ILAR RF+ poly classification (100% vs 77%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>A number of children with RF+ arthritis were excluded from the RF+ poly JIA classification, though many demographic features and disease measures were similar to those of children who met criteria for RF+ poly JIA. We propose prioritization of RF\/anti-CCP positivity over specific exclusions, along with inclusion of anti-CCP, in future revisions of the JIA classification criteria, to improve the sensitivity of diagnosing childhood-onset RA.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.130563","type":"journal-article","created":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T20:27:29Z","timestamp":1391286449000},"page":"547-553","source":"Crossref","is-referenced-by-count":15,"title":["Limitations in the Classification of Childhood-onset Rheumatoid Arthritis"],"prefix":"10.3899","volume":"41","author":[{"given":"Emily G.","family":"Ferrell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori A.","family":"Ponder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren S.","family":"Minor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila T.","family":"Angeles-Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine W.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly A.","family":"Rouster-Stevens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Rohani-Pichavant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry B.","family":"Vogler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sampath","family":"Prahalad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2014,2,1]]},"reference":[{"key":"2018112909325331000_41.3.547.1","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty","year":"2004","journal-title":"J Rheumatol"},{"key":"2018112909325331000_41.3.547.2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290216"},{"key":"2018112909325331000_41.3.547.3","first-page":"1989","article-title":"Disease course and outcome of juvenile rheumatoid arthritis in a multicenter cohort","volume":"29","author":"Oen","year":"2002","journal-title":"J Rheumatol"},{"key":"2018112909325331000_41.3.547.4","doi-asserted-by":"publisher","DOI":"10.1002\/art.10863"},{"key":"2018112909325331000_41.3.547.5","doi-asserted-by":"publisher","DOI":"10.1002\/art.10783"},{"key":"2018112909325331000_41.3.547.6","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20044"},{"key":"2018112909325331000_41.3.547.7","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.76"},{"key":"2018112909325331000_41.3.547.8","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"2018112909325331000_41.3.547.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2012.03.008"},{"key":"2018112909325331000_41.3.547.10","doi-asserted-by":"publisher","DOI":"10.1080\/08820130802438057"},{"key":"2018112909325331000_41.3.547.11","doi-asserted-by":"publisher","DOI":"10.1002\/art.20773"},{"key":"2018112909325331000_41.3.547.12","first-page":"492","article-title":"Measurement of biomarkers in juvenile idiopathic arthritis patients and their significant association with disease severity: a comparative study","volume":"26","author":"Gilliam","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"2018112909325331000_41.3.547.13","first-page":"1900","article-title":"Are the number of joints involved or the presence of psoriasis still useful tools to identify homogeneous disease entities in juvenile idiopathic arthritis?","volume":"30","author":"Martini","year":"2003","journal-title":"J Rheumatol"},{"key":"2018112909325331000_41.3.547.14","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201388"},{"key":"2018112909325331000_41.3.547.15","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-11-200706050-00008"},{"key":"2018112909325331000_41.3.547.16","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-10-29"},{"key":"2018112909325331000_41.3.547.17","doi-asserted-by":"publisher","DOI":"10.1002\/art.11223"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.130563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T13:32:24Z","timestamp":1543498344000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.130563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,1]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,1]]},"published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.3899\/jrheum.130563"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.130563","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,1]]}}}