{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:30:37Z","timestamp":1762079437969},"reference-count":20,"publisher":"The Journal of Rheumatology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Hypervascularization in finger clubbing is recognized, but its microanatomical basis remains unclear. This pilot descriptive study used magnetic resonance imaging (MRI) to explore this further.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>High-resolution MRI acquired with contrast agent was carried out in 4 patients with finger clubbing and 4 healthy volunteers. The anatomy of the nail bed, capsular structures, and bony changes were described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Marked nail bed thickening and contrast enhancement was noted in all clubbed fingers, with bone edema in 3 of the 4 patients. None of the healthy subjects had similar abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>This confirms that hypervascularization of the nail bed observed in the microanatomy on high-resolution MRI is associated with clubbed appearances of the nails.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.130823","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T23:53:52Z","timestamp":1389830032000},"page":"523-527","source":"Crossref","is-referenced-by-count":16,"title":["The Microanatomic Basis of Finger Clubbing \u2014 A High-resolution Magnetic Resonance Imaging Study"],"prefix":"10.3899","volume":"41","author":[{"given":"Junichi","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola Ann","family":"Halliday","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Fukuba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Radjenovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven F.","family":"Tanner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Emery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"McGonagle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai Lyn","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2014,1,15]]},"reference":[{"key":"2018112909325330000_41.3.523.1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.3.341"},{"key":"2018112909325330000_41.3.523.2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21210"},{"key":"2018112909325330000_41.3.523.3","doi-asserted-by":"publisher","DOI":"10.1002\/art.21736"},{"key":"2018112909325330000_41.3.523.4","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.172"},{"key":"2018112909325330000_41.3.523.5","doi-asserted-by":"publisher","DOI":"10.1161\/hc4501.098020"},{"key":"2018112909325330000_41.3.523.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)93302-6"},{"key":"2018112909325330000_41.3.523.7","first-page":"21","article-title":"Prevalence of digital clubbing in bronchogenic carcinoma by a new digital index","volume":"16","author":"Baughman","year":"1998","journal-title":"Clin Exp Rheumatol"},{"key":"2018112909325330000_41.3.523.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05596.x"},{"key":"2018112909325330000_41.3.523.9","doi-asserted-by":"publisher","DOI":"10.1136\/ard.42.1.98"},{"key":"2018112909325330000_41.3.523.10","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/S0140-6736(87)91132-9","article-title":"Megakaryocytes and platelet clumps as the cause of finger clubbing","volume":"2","author":"Dickinson","year":"1987","journal-title":"Lancet"},{"key":"2018112909325330000_41.3.523.11","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90452-U"},{"key":"2018112909325330000_41.3.523.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2006.11.004"},{"key":"2018112909325330000_41.3.523.13","doi-asserted-by":"publisher","DOI":"10.1378\/chest.107.4.1172"},{"key":"2018112909325330000_41.3.523.14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMicm066228"},{"key":"2018112909325330000_41.3.523.15","first-page":"629","article-title":"Takayasu\u2019s arteritis with transient clubbed finger","volume":"17","author":"Ishikawa","year":"1999","journal-title":"Clin Exp Rheumatol"},{"key":"2018112909325330000_41.3.523.16","first-page":"614","article-title":"Circulating vascular endothelial growth factor concentrations in a case of pulmonary hypertrophic osteoarthropathy. 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