{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:52:44Z","timestamp":1793379164140,"version":"4.5.0"},"reference-count":26,"publisher":"The Journal of Rheumatology","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To investigate the joint effects of alcohol consumption and <jats:italic>ABCG2<\/jats:italic> gene variants on tophaceous gout occurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>The V12M (rs2231137), Q126X (rs72552713), and Q141K (rs2231142) of the <jats:italic>ABCG2<\/jats:italic> gene were genotyped among controls, nontophaceous, and tophaceous gout cases in Taiwanese Han (n = 446, 77, 177) and Taiwan Aborigines (n = 1105, 203, 330).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>The missense variations V12M (C) and Q141K (T) significantly associated with tophaceous gout (p trend = 4.08 \u00d7 10<jats:sup>\u22122<\/jats:sup>, 9.00 \u00d7 10<jats:sup>\u221212<\/jats:sup> in Han; 1.81 \u00d7 10<jats:sup>\u22123<\/jats:sup>, 9.34 \u00d7 10<jats:sup>\u221210<\/jats:sup> in Aborigines). The nonsense variation Q126X (T) exerted a significant effect only in Han (p = 1.10 \u00d7 10<jats:sup>\u22122<\/jats:sup>), but not in Aborigines. In the prediction of tophaceous gout, the Q141K (T) OR were 1.51 in Han, 1.50 in Aborigines, and 1.55 (p = 7.84 \u00d7 10<jats:sup>\u22125<\/jats:sup>) in pooled analysis when compared to nontophaceous gout. We found the joint effects of alcohol consumption and Q141K (T\/T) highly associated with tophaceous gout (adjusted OR \u2265 5.11; p \u2264 7.78 \u00d7 10<jats:sup>\u22124<\/jats:sup>); specifically the ever drinkers carrying the Q141K (T\/T; adjusted OR 25.05, p = 9.21 \u00d7 10<jats:sup>\u22124<\/jats:sup> in Han; adjusted OR 14.87, p = 1.08 \u00d7 10<jats:sup>\u22128<\/jats:sup> in Aborigines).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Our findings showed alcohol consumption and <jats:italic>ABCG2<\/jats:italic> Q141K, independently and jointly, associated with the risk of chronic tophaceous gout.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.130870","type":"journal-article","created":{"date-parts":[[2014,2,16]],"date-time":"2014-02-16T01:40:20Z","timestamp":1392514820000},"page":"749-758","source":"Crossref","is-referenced-by-count":34,"title":["Joint Effects of Alcohol Consumption and <i>ABCG2<\/i> Q141K on Chronic Tophaceous Gout Risk"],"prefix":"10.3899","volume":"41","author":[{"given":"Hung-Pin","family":"Tu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert Min-Shan","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang-Lun","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Shin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Ming","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Min","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Ming","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Hung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzer-Min","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Jung","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Chin","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2014,2,15]]},"reference":[{"key":"2018112909324008000_41.4.749.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60883-7"},{"key":"2018112909324008000_41.4.749.2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-7-200510040-00009"},{"key":"2018112909324008000_41.4.749.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2007.12.021"},{"key":"2018112909324008000_41.4.749.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16000-5"},{"key":"2018112909324008000_41.4.749.5","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000237"},{"key":"2018112909324008000_41.4.749.6","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.144"},{"key":"2018112909324008000_41.4.749.7","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00039.2004"},{"key":"2018112909324008000_41.4.749.8","doi-asserted-by":"publisher","DOI":"10.1086\/423429"},{"key":"2018112909324008000_41.4.749.9","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.093252"},{"key":"2018112909324008000_41.4.749.10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901249106"},{"key":"2018112909324008000_41.4.749.11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1214530110"},{"key":"2018112909324008000_41.4.749.12","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200320"},{"key":"2018112909324008000_41.4.749.13","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.113357"},{"key":"2018112909324008000_41.4.749.14","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt028"},{"key":"2018112909324008000_41.4.749.15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600727"},{"key":"2018112909324008000_41.4.749.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61343-4"},{"key":"2018112909324008000_41.4.749.17","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"2018112909324008000_41.4.749.18","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq412"},{"key":"2018112909324008000_41.4.749.19","doi-asserted-by":"crossref","unstructured":"Zhang L Spencer KL Voruganti VS Jorgensen NW Fornage M Best LG Association of functional polymorphism rs2231142 (Q141K) in the ABCG2 gene with serum uric acid and gout in 4 US populations: the PAGE study. 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