{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:29:15Z","timestamp":1791829755284,"version":"4.3.4"},"reference-count":16,"publisher":"The Journal of Rheumatology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To describe the Israeli experience of treating adult-onset Still\u2019s disease (AOSD) with tocilizumab (TCZ).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Israeli rheumatologists who treated AOSD with TCZ filled in questionnaires on symptoms, number of tender and swollen joints, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and dosage of prednisone at initial TCZ administration, after 6 months, and at the end of followup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Nine male and 6 female patients, aged 33 \u00b1 12 years, mean disease duration 9 years (range: 1\u201325) were identified. They had used a mean of 3.6 disease-modifying drugs, including 10 patients with tumor necrosis factor blockers. Intravenous TCZ 8 mg\/kg was administered every 4 weeks (12 patients) or every 2 weeks (3 patients). All patients completed at least 6 months of treatment. The mean followup period was 15.7 \u00b1 9 months. At the onset of therapy, despite the use of prednisone (27.6 \u00b1 26.3 mg\/d), all patients reported joint pain. Fever was reported in 9 patients, rash in 7, pleuritis in 3, and hepatitis in 2 before TCZ use, with mean ESR and CRP levels of 60 \u00b1 28 mm\/h and 11.6 \u00b1 15 mg\/dl, respectively. After 6 months of treatment and at the end of followup, the number of tender and swollen joints, the ESR and CRP levels, and the prednisone dosage decreased significantly. Only 2 patients still complained of mild arthralgias, and none reported systemic symptoms at the end of followup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>TCZ 8 mg\/kg was extremely efficacious in treating adult patients with refractory Still\u2019s disease. Both TCZ and interleukin 1 blockade should be considered in the treatment algorithm of AOSD. Randomized controlled studies are needed to validate these findings.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.130881","type":"journal-article","created":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T04:53:52Z","timestamp":1389848032000},"page":"244-247","source":"Crossref","is-referenced-by-count":47,"title":["Tocilizumab in Adult-onset Still\u2019s Disease: the Israeli Experience"],"prefix":"10.3899","volume":"41","author":[{"given":"Ori","family":"Elkayam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nizar","family":"Jiries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zvi","family":"Dranitzki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shay","family":"Kivity","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merav","family":"Lidar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Ablin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Abu-Shakra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagit","family":"Savargyl-Maman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagit","family":"Padova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Caspi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itzhak","family":"Rosner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2014,1,15]]},"reference":[{"key":"2018112909322695000_41.2.244.1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.30.2.121"},{"key":"2018112909322695000_41.2.244.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2008.08.006"},{"key":"2018112909322695000_41.2.244.3","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3800"},{"key":"2018112909322695000_41.2.244.4","doi-asserted-by":"publisher","DOI":"10.1002\/art.21061"},{"key":"2018112909322695000_41.2.244.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60454-7"},{"key":"2018112909322695000_41.2.244.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112802"},{"key":"2018112909322695000_41.2.244.7","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20319"},{"key":"2018112909322695000_41.2.244.8","doi-asserted-by":"publisher","DOI":"10.1007\/s10165-011-0569-6"},{"key":"2018112909322695000_41.2.244.9","first-page":"424","article-title":"Preliminary criteria for classification of adult Still\u2019s disease","volume":"19","author":"Yamaguchi","year":"1992","journal-title":"J Rheumatol"},{"key":"2018112909322695000_41.2.244.10","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-012-2105-2"},{"key":"2018112909322695000_41.2.244.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.02.006"},{"key":"2018112909322695000_41.2.244.12","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-10-30"},{"key":"2018112909322695000_41.2.244.13","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e318205092d"},{"key":"2018112909322695000_41.2.244.14","doi-asserted-by":"publisher","DOI":"10.1007\/s10165-010-0365-8"},{"key":"2018112909322695000_41.2.244.15","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2013.854048"},{"key":"2018112909322695000_41.2.244.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2012.07.002"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.130881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T18:34:39Z","timestamp":1543516479000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.130881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,15]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,2,1]]},"published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.3899\/jrheum.130881"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.130881","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,15]]}}}