{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:08:34Z","timestamp":1787972914093,"version":"build-2784847793"},"reference-count":45,"publisher":"The Journal of Rheumatology","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To compare the initial clinical, biological, and radiographic findings of early arthritis by positivity for rheumatoid factor (RF) and\/or anticyclic citrullinated peptide antibodies (anti-CCP), and to validate a patient profile based on this serologic information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>The ESPOIR cohort comprises patients presenting synovitis of at least 2 joints for 6 weeks to 6 months. Patients underwent testing for IgM rheumatoid factor (IgM-RF) and anti-CCP2 antibodies and were divided into 4 groups: RF\u2013 and anti-CCP\u2013 (group 1), RF+ and anti-CCP\u2013 (group 2), RF\u2013 and anti-CCP+ (group 3), RF+ and anti-CCP+ (group 4). We compared the groups in terms of clinical, biological, and radiographic features (baseline scores and 6-month and 12-month progression).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Of the 813 recruited patients, 406 (50%) were in group 1, 91 (11.2%) in group 2, 34 (4.1%) in group 3, and 281 (34.6%) in group 4. Mean baseline erythrocyte sedimentation rate and C-reactive protein were higher for anti-CCP+ groups (groups 3 and 4) than for other groups (p &lt; 0.001), and van der Heijde-modified Sharp score for radiographs was higher for group 4 than for other groups (p &lt; 0.001). Clinical presentation was not consistently associated with serologic profile. Radiographic progression at 1 year was higher for anti-CCP+ groups than other groups (p &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>The phenotype of patients with early arthritis with or without anti-CCP and\/or RF positivity did not correspond to a particular clinical presentation. However, baseline acute-phase reactants and short-term radiographic progression were high in patients with anti-CCP positivity, which may be associated with the inflammatory process and progressive disease in patients with early arthritis.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.130884","type":"journal-article","created":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T04:56:46Z","timestamp":1405486606000},"page":"1614-1622","source":"Crossref","is-referenced-by-count":20,"title":["Association of Anticyclic Citrullinated Peptide Antibodies and\/or Rheumatoid Factor Status and Clinical Presentation in Early Arthritis: Results from the ESPOIR 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