{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:06:57Z","timestamp":1791216417709,"version":"4.1.0"},"reference-count":25,"publisher":"The Journal of Rheumatology","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To evaluate the outcome of resistive home exercise and its possible longterm influence on health, disability, and disease activity in patients with active polymyositis (PM) or dermatomyositis (DM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Nineteen patients with recent-onset PM\/DM were included after introduction of high-dose prednisolone. They were assessed by independent assessors as to perceived health, muscle performance, aerobic capacity, and serum creatine phosphokinase (CPK) at baseline and after 24 weeks, including repeated muscle biopsies at 24 weeks (single-blinded randomized controlled study), and in an open-label followup at 52, 78, and 104 weeks. Patients were randomized to 12 weeks, 5 days\/week resistive home exercise with telephone support and encouragement for another 12 weeks of twice-a-week home or gym exercise (EG, n = 10) or to 24 weeks, 5 days\/week range of motion exercise (CG, n = 9). Patients in the CG group without inflammatory infiltrates in muscle biopsies at 24 weeks were invited to the 12-week resistive home exercises.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>At baseline, the EG had poorer perceived health, but otherwise the groups were comparable. At 24 weeks, both groups improved in muscle performance and aerobic capacity (p &lt; 0.001 to &lt; 0.05) with no signs of increased inflammation assessed by CPK levels or muscle biopsies. Both groups improved in muscle performance and aerobic capacity up to 52 weeks (p &lt; 0.05) lasting to 104 weeks in the EG (p &lt; 0.05) and presented minor improvements in perceived health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Our study supports the safety of resistive exercise in patients with active PM\/DM but did not reveal any between-group differences in exercise effects. An individually adapted physical therapist\u2013supervised home exercise program might be recommended in early active PM\/DM, with regular evaluation of muscle performance and health.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.131145","type":"journal-article","created":{"date-parts":[[2014,5,2]],"date-time":"2014-05-02T03:35:07Z","timestamp":1399001707000},"page":"1124-1132","source":"Crossref","is-referenced-by-count":75,"title":["Resistive Home Exercise in Patients with Recent-onset Polymyositis and Dermatomyositis \u2014 A Randomized Controlled Single-blinded Study with a 2-year Followup"],"prefix":"10.3899","volume":"41","author":[{"given":"Helene","family":"Alexanderson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Alemo","family":"Munters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Dastmalchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingela","family":"Loell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Heimb\u00fcrger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina H.","family":"Opava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid E.","family":"Lundberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2014,5,1]]},"reference":[{"key":"2018112909325342000_41.6.1124.1","doi-asserted-by":"publisher","DOI":"10.1517\/14656560902913815"},{"key":"2018112909325342000_41.6.1124.2","first-page":"2230","article-title":"Polymyositis and dermatomyositis: short term and longterm outcome, and predictive factors of prognosis","volume":"28","author":"Marie","year":"2001","journal-title":"J Rheumatol"},{"key":"2018112909325342000_41.6.1124.3","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh404"},{"key":"2018112909325342000_41.6.1124.4","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.1.22"},{"key":"2018112909325342000_41.6.1124.5","first-page":"1399","article-title":"Isometric exercise increases strength and does not produce sustained creatine phosphokinase in a patient with polymyositis","volume":"20","author":"Hicks","year":"1993","journal-title":"J Rheumatol"},{"key":"2018112909325342000_41.6.1124.6","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/37.2.196"},{"key":"2018112909325342000_41.6.1124.7","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.7.608"},{"key":"2018112909325342000_41.6.1124.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9406(05)60764-X"},{"key":"2018112909325342000_41.6.1124.9","doi-asserted-by":"publisher","DOI":"10.1002\/art.21185"},{"key":"2018112909325342000_41.6.1124.10","doi-asserted-by":"publisher","DOI":"10.1002\/art.22780"},{"key":"2018112909325342000_41.6.1124.11","first-page":"1340","article-title":"Resistive exercise in the rehabilitation of Polymyositis\/dermatomyositis","volume":"20","author":"Escalante","year":"1993","journal-title":"J Rheumatol"},{"key":"2018112909325342000_41.6.1124.12","doi-asserted-by":"publisher","DOI":"10.1191\/0269215503cr572oa"},{"key":"2018112909325342000_41.6.1124.13","doi-asserted-by":"publisher","DOI":"10.1080\/030097400447679"},{"key":"2018112909325342000_41.6.1124.14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"2018112909325342000_41.6.1124.15","first-page":"1380","article-title":"A functional index in myositis","volume":"23","author":"Josefson","year":"1996","journal-title":"J Rheumatol"},{"key":"2018112909325342000_41.6.1124.16","first-page":"1517","article-title":"Validity and reliability of a submaximal treadmill test to estimate aerobic capacity in women with rheumatic disease","volume":"23","author":"Minor","year":"1996","journal-title":"J Rheumatol"},{"key":"2018112909325342000_41.6.1124.17","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1249\/00005768-198205000-00012","article-title":"Psychophysical bases of perceived exertion","volume":"14","author":"Borg","year":"1982","journal-title":"Med Sci Sports Exerc"},{"key":"2018112909325342000_41.6.1124.18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/140349489402200102","article-title":"Health-related quality of life in old age. 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